Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism

Prior studies showed that Axl /Tyro3 null mice have delayed first estrus and abnormal cyclicity due to developmental defects in GnRH neuron migration and survival. The objective of the study was to test whether the absence of Axl would alter reproductive function in mice and that mutations in AXL ar...

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Vydané v:	The journal of clinical endocrinology and metabolism Ročník 99; číslo 4; s. 1452
Hlavní autori:	Salian-Mehta, S, Xu, M, Knox, A J, Plummer, L, Slavov, D, Taylor, M, Bevers, S, Hodges, R S, Crowley, Jr, W F, Wierman, M E
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.04.2014
Predmet:	Adolescent Adult Animals Cells, Cultured Female Genetic Association Studies Humans Hypogonadism - genetics Kallmann Syndrome - genetics Male Mice Mice, Inbred C57BL Mice, Knockout Pedigree Polymorphism, Single Nucleotide Proto-Oncogene Proteins - genetics Receptor Protein-Tyrosine Kinases - genetics Sexual Maturation - genetics Young Adult
ISSN:	1945-7197, 1945-7197
On-line prístup:	Zistit podrobnosti o prístupe
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