Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism

Prior studies showed that Axl /Tyro3 null mice have delayed first estrus and abnormal cyclicity due to developmental defects in GnRH neuron migration and survival. The objective of the study was to test whether the absence of Axl would alter reproductive function in mice and that mutations in AXL ar...

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Bibliographic Details
Published in:	The journal of clinical endocrinology and metabolism Vol. 99; no. 4; p. 1452
Main Authors:	Salian-Mehta, S, Xu, M, Knox, A J, Plummer, L, Slavov, D, Taylor, M, Bevers, S, Hodges, R S, Crowley, Jr, W F, Wierman, M E
Format:	Journal Article
Language:	English
Published:	United States 01.04.2014
Subjects:	Adolescent Adult Animals Cells, Cultured Female Genetic Association Studies Humans Hypogonadism - genetics Kallmann Syndrome - genetics Male Mice Mice, Inbred C57BL Mice, Knockout Pedigree Polymorphism, Single Nucleotide Proto-Oncogene Proteins - genetics Receptor Protein-Tyrosine Kinases - genetics Sexual Maturation - genetics Young Adult
ISSN:	1945-7197, 1945-7197
Online Access:	Get more information
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