Functional immune cell-astrocyte interactions

Astrocytes are abundant glial cells in the central nervous system (CNS) that control multiple aspects of health and disease. Through their interactions with components of the blood-brain barrier (BBB), astrocytes not only regulate BBB function, they also sense molecules produced by peripheral immune...

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Bibliographic Details
Published in:The Journal of experimental medicine Vol. 218; no. 9
Main Authors: Sanmarco, Liliana M, Polonio, Carolina M, Wheeler, Michael A, Quintana, Francisco J
Format: Journal Article
Language:English
Published: United States 06.09.2021
Subjects:
Astrocytes - cytology
Astrocytes - physiology
Blood-Brain Barrier
Cell Communication
Humans
Killer Cells, Natural - immunology
Killer Cells, Natural - physiology
Microglia - cytology
Microglia - metabolism
Multiple Sclerosis - immunology
Multiple Sclerosis - pathology
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
ISSN:1540-9538, 1540-9538
Online Access:Get more information
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Summary:Astrocytes are abundant glial cells in the central nervous system (CNS) that control multiple aspects of health and disease. Through their interactions with components of the blood-brain barrier (BBB), astrocytes not only regulate BBB function, they also sense molecules produced by peripheral immune cells, including cytokines. Here, we review the interactions between immune cells and astrocytes and their roles in health and neurological diseases, with a special focus on multiple sclerosis (MS). We highlight known pathways that participate in astrocyte crosstalk with microglia, NK cells, T cells, and other cell types; their contribution to the pathogenesis of neurological diseases; and their potential value as therapeutic targets.
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ISSN:1540-9538
1540-9538
DOI:10.1084/jem.20202715