Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes

Recent worldwide reports of community-onset skin abscesses, outbreaks of furunculosis, and severe pneumonia associated with methicillin-resistant Staphylococcus aureus (MRSA) carrying Panton-Valentine leukocidin (PVL) genes and the staphylococcal cassette chromosome mec (SCCmec) type IV indicate tha...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Clinical infectious diseases Ročník 40; číslo 1; s. 100
Hlavní autori: Francis, John S, Doherty, Meg C, Lopatin, Uri, Johnston, Cecilia P, Sinha, Gita, Ross, Tracy, Cai, Mian, Hansel, Nadia N, Perl, Trish, Ticehurst, John R, Carroll, Karen, Thomas, David L, Nuermberger, Eric, Bartlett, John G
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.01.2005
Predmet:
Adult
Bacterial Toxins
Bacterial Typing Techniques
Community-Acquired Infections - microbiology
Exotoxins
Female
Humans
Leukocidins - genetics
Male
Methicillin - pharmacology
Methicillin Resistance
Middle Aged
Patient Selection
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcus aureus - classification
Staphylococcus aureus - drug effects
Staphylococcus aureus - genetics
Staphylococcus aureus - pathogenicity
Virulence Factors - analysis
ISSN:1537-6591, 1537-6591
On-line prístup:Zistit podrobnosti o prístupe
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Recent worldwide reports of community-onset skin abscesses, outbreaks of furunculosis, and severe pneumonia associated with methicillin-resistant Staphylococcus aureus (MRSA) carrying Panton-Valentine leukocidin (PVL) genes and the staphylococcal cassette chromosome mec (SCCmec) type IV indicate that MRSA infections are evolving into a community-related problem. The majority of cases reported to date involve skin and soft-tissue infections, with severe pneumonia representing a relatively rare phenomenon. During a 2-month period in the winter of 2003-2004, four healthy adults presented to 1 of 2 Baltimore hospitals with severe necrotizing MRSA pneumonia in the absence of typical risk factors for MRSA infection. Patients' MRSA isolates were characterized by strain typing with use of pulsed-field gel electrophoresis and SCCmec typing with use of a multiplex polymerase chain reaction (PCR) assay and detection of PVL genes by PCR. All 4 patients' MRSA isolates carried the PVL genes and the SCCmec type IV element and belonged to the USA300 pulsed-field type. These 3 findings are among the typical characteristics of community-onset MRSA strains. In addition, 2 of our patients had concomitant influenza A diagnosed, which likely contributed to the severity of their presentation. To our knowledge, these patients represent the first reported North American adults with severe community-onset MRSA pneumonia caused by strains carrying the PVL genes.
Bibliografia:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:1537-6591
1537-6591
DOI:10.1086/427148