Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia Rats

Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain and an extensive array of other symptoms including disordered sleep, fatigue, depression and anxiety. Important factors involved in the pathogenic process of fibromyalgia are inflammation and oxidative stress, sugges...

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Vydané v:International journal of molecular sciences Ročník 18; číslo 7; s. 1389
Hlavní autori: Favero, Gaia, Trapletti, Valentina, Bonomini, Francesca, Stacchiotti, Alessandra, Lavazza, Antonio, Rodella, Luigi, Rezzani, Rita
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI 29.06.2017
Predmet:
Administration, Oral
Analysis of Variance
Animals
Antioxidants - pharmacology
Body Weight - drug effects
Disease Models, Animal
Fibromyalgia - drug therapy
Inflammation - drug therapy
Male
Melatonin - pharmacology
Microscopy, Electron, Transmission
Muscle, Skeletal - drug effects
Muscle, Skeletal - pathology
Muscle, Skeletal - ultrastructure
Musculoskeletal Diseases - drug therapy
Myalgia - drug therapy
Oxidative Stress - drug effects
Protective Agents - pharmacology
Rats
Rats, Sprague-Dawley
Reserpine - pharmacology
Sulfhydryl Compounds - analysis
melatonin
skeletal muscle
fibromyalgia
inflammation
oxidative stress
ISSN:1422-0067, 1422-0067
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Shrnutí:Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain and an extensive array of other symptoms including disordered sleep, fatigue, depression and anxiety. Important factors involved in the pathogenic process of fibromyalgia are inflammation and oxidative stress, suggesting that ant-inflammatory and/or antioxidant supplementation might be effective in the management and modulation of this syndrome. Recent evidence suggests that melatonin may be suitable for this purpose due to its well known ant-inflammatory, antioxidant and analgesic effects. Thus, in the current study, the effects of the oral supplementation of melatonin against fibromyalgia-related skeletal muscle alterations were evaluated. In detail, 90 Sprague Dawley rats were randomly treated with reserpine, to reproduce the pathogenic process of fibromyalgia and thereafter they received melatonin. The animals treated with reserpine showed moderate alterations at hind limb skeletal muscles level and had difficulty in moving, together with significant morphological and ultrastructural alterations and expression of inflammatory and oxidative stress markers in the gastrocnemius muscle. Interestingly, melatonin, dose and/or time dependently, reduced the difficulties in spontaneous motor activity and the musculoskeletal morphostructural, inflammatory, and oxidative stress alterations. This study suggests that melatonin in vivo may be an effective tool in the management of fibromyalgia-related musculoskeletal morphofunctional damage.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1422-0067
1422-0067
DOI:10.3390/ijms18071389