Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria

Mechanisms that regulate cellular metabolism are a fundamental requirement of all cells. Most eukaryotic cells rely on aerobic mitochondrial metabolism to generate ATP. Nevertheless, regulation of mitochondrial activity is incompletely understood. Here we identified an unexpected and essential role...

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Vydané v:Cell Ročník 142; číslo 2; s. 270
Hlavní autori: Cárdenas, César, Miller, Russell A, Smith, Ian, Bui, Thi, Molgó, Jordi, Müller, Marioly, Vais, Horia, Cheung, King-Ho, Yang, Jun, Parker, Ian, Thompson, Craig B, Birnbaum, Morris J, Hallows, Kenneth R, Foskett, J Kevin
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 23.07.2010
Predmet:
Animals
Autophagy
B-Lymphocytes - metabolism
Calcium - metabolism
Calcium Signaling
Cell Line
Chickens
Gene Knockout Techniques
Inositol 1,4,5-Trisphosphate Receptors - metabolism
Mitochondria - metabolism
Oxidative Phosphorylation
ISSN:1097-4172, 1097-4172
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Shrnutí:Mechanisms that regulate cellular metabolism are a fundamental requirement of all cells. Most eukaryotic cells rely on aerobic mitochondrial metabolism to generate ATP. Nevertheless, regulation of mitochondrial activity is incompletely understood. Here we identified an unexpected and essential role for constitutive InsP(3)R-mediated Ca(2+) release in maintaining cellular bioenergetics. Macroautophagy provides eukaryotes with an adaptive response to nutrient deprivation that prolongs survival. Constitutive InsP(3)R Ca(2+) signaling is required for macroautophagy suppression in cells in nutrient-replete media. In its absence, cells become metabolically compromised due to diminished mitochondrial Ca(2+) uptake. Mitochondrial uptake of InsP(3)R-released Ca(2+) is fundamentally required to provide optimal bioenergetics by providing sufficient reducing equivalents to support oxidative phosphorylation. Absence of this Ca(2+) transfer results in enhanced phosphorylation of pyruvate dehydrogenase and activation of AMPK, which activates prosurvival macroautophagy. Thus, constitutive InsP(3)R Ca(2+) release to mitochondria is an essential cellular process that is required for efficient mitochondrial respiration and maintenance of normal cell bioenergetics.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2010.06.007