Evaluation of T-cell responses to novel RD1- and RD2-encoded Mycobacterium tuberculosis gene products for specific detection of human tuberculosis infection

The tuberculin skin test for diagnosing Mycobacterium tuberculosis infection suffers from antigenic cross-reactivity of purified protein derivative with BCG, resulting in poor specificity in BCG-vaccinated populations. Comparative genomics has identified several genetic regions in M. tuberculosis an...

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Bibliographic Details
Published in:	Infection and immunity Vol. 72; no. 5; p. 2574
Main Authors:	Liu, Xiao-Qing, Dosanjh, Davinder, Varia, Hansa, Ewer, Katie, Cockle, Paul, Pasvol, Geoffrey, Lalvani, Ajit
Format:	Journal Article
Language:	English
Published:	United States 01.05.2004
Subjects:	Adolescent Adult Aged Amino Acid Sequence Antigens, Bacterial - genetics Bacterial Proteins - genetics Bacterial Proteins - immunology BCG Vaccine - immunology Case-Control Studies Cross Reactions Female Genes, Bacterial Humans In Vitro Techniques Interferon-gamma - biosynthesis Male Middle Aged Molecular Sequence Data Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - immunology Prospective Studies Sensitivity and Specificity T-Lymphocytes - immunology Tuberculosis - diagnosis Tuberculosis - immunology Tuberculosis - microbiology
ISSN:	0019-9567
Online Access:	Get more information
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