Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice

We have generated mouse models of malignant mesothelioma (MM) based upon disruption of the Bap1, Nf2, and Cdkn2ab tumor suppressor loci in various combinations as also frequently observed in human MM. Inactivation of all three loci in the mesothelial lining of the thoracic cavity leads to a highly a...

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Veröffentlicht in:	The Journal of experimental medicine Jg. 217; H. 6
Hauptverfasser:	Badhai, Jitendra, Pandey, Gaurav Kumar, Song, Ji-Ying, Krijgsman, Oscar, Bhaskaran, Rajith, Chandrasekaran, Gayathri, Kwon, Min-Chul, Bombardelli, Lorenzo, Monkhorst, Kim, Grasso, Cristoforo, Zevenhoven, John, van der Vliet, Jan, Cozijnsen, Miranda, Krimpenfort, Paul, Peeper, Daniel, van Lohuizen, Maarten, Berns, Anton
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.06.2020
Schlagworte:	Animals Cyclin-Dependent Kinase Inhibitor p15 - metabolism Cyclin-Dependent Kinase Inhibitor p16 - metabolism Disease Models, Animal Disease Progression Gene Deletion Humans Immunophenotyping MAP Kinase Signaling System - drug effects Mesothelioma, Malignant - genetics Mesothelioma, Malignant - metabolism Mesothelioma, Malignant - pathology Mice Neurofibromin 2 - metabolism Phosphatidylinositol 3-Kinases - metabolism Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Protein Kinase Inhibitors - pharmacology Transcription, Genetic - drug effects Tumor Microenvironment - drug effects Tumor Suppressor Proteins - metabolism Ubiquitin Thiolesterase - metabolism
ISSN:	1540-9538, 1540-9538
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