Polymorphisms in HLA-C and KIR alleles are not associated with HAM/TSP risk in HTLV-1-infected subjects

Several genetic polymorphisms may be related to susceptibility or resistance to viral disease outcomes. Immunological or genetic factors may act as major triggers of the immune pathogenesis of HAM/TSP. This study investigated the association of immune related genetic polymorphisms with viral and imm...

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Published in:Virus research Vol. 244; pp. 71 - 74
Main Authors: Assone, Tatiane, Malta, Fernanda M., Bakkour, Sonia, Montalvo, Leilani, Paiva, Arthur M., Smid, Jerusa, de Oliveira, Augusto César Penalva, de Toledo Gonçalves, Fernanda, do Carmo Luiz, Olinda, Fonseca, Luiz Augusto M., Norris, Philip J., Casseb, Jorge
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 15.01.2018
Subjects:
alleles
genetic factors
genetic polymorphism
genotype
HLA antigens
HTLV-1
immunologic factors
infectious diseases
Interferons
lymphocyte proliferation
pathogenesis
patients
Polymorphisms
Primate T-lymphotropic virus 1
risk
HLA antigens
HTLV-1
Polymorphisms
Interferons
ISSN:0168-1702, 1872-7492, 1872-7492
Online Access:Get full text
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Summary:Several genetic polymorphisms may be related to susceptibility or resistance to viral disease outcomes. Immunological or genetic factors may act as major triggers of the immune pathogenesis of HAM/TSP. This study investigated the association of immune related genetic polymorphisms with viral and immunological markers. 247 HTLV-1-infected volunteers, drawn from a larger group of HTLV-infected subjects followed at the Institute of Infectious Diseases “Emilio Ribas” (IIER) for up to 19 years, participated in this study, which ran from June 2011 to July 2016. The subjects were classified according to their neurological status into two groups: Group 1 (160 asymptomatic individuals) and Group 2 (87 HAM/TSP patients). Samples were tested for spontaneous lymphocyte proliferation (LPA) and HTLV-1 proviral load (PVL) and for IFN-λ4, HLA-C and KIR genotypes using qPCR. We found associations between LPA (p=0.0001) with HAM/TSP and confirmed the IFN-λ4 polymorphism rs8099917, allele GG, as a protective factor using a recessive model (OR=3.22, CI=1.10–9.47). Polymorphisms in HLA-C and KIR alleles were not associated with risk of developing HAM/TSP. We demonstrated that age, LPA and an IFN-λ4 polymorphism were associated with progression to HAM/TSP. Understanding HAM/TSP pathogenesis can provide important markers of prognostic value for clinical management, and contribute to the discovery of new therapeutic interventions in the future.
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ISSN:0168-1702
1872-7492
1872-7492
DOI:10.1016/j.virusres.2017.11.010