Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population

To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not as...

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Veröffentlicht in:	European journal of human genetics : EJHG Jg. 16; H. 6; S. 762 - 765
Hauptverfasser:	Blanton, Ronald E, Silva, Luciano K, Morato, Vanessa G, Parrado, Antonio R, Dias, Juarez P, Melo, Paulo R S, Reis, Eliana A G, Goddard, Katrina A B, Nunes, Márcio R T, Rodrigues, Sueli G, Vasconcelos, Pedro F C, Castro, Jesuina M, Reis, Mitermayer G, Barreto, Maurício L, Teixeira, M Glória
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Cham Springer International Publishing 01.06.2008 Nature Publishing Nature Publishing Group
Schlagworte:	African Continental Ancestry Group - genetics Arboviroses Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedicine Brazil Cytogenetics Dengue - genetics Dengue fever Dengue fevers Dengue hemorrhagic fever Diagnosis Disease Epidemics Epidemiology Ethnic groups Ethnicity Fever Fundamental and applied biological sciences. Psychology Gene Expression General aspects. Genetic counseling Genetics Genetics of eukaryotes. Biological and molecular evolution Genotype Human Genetics Human viral diseases Humans Income Infectious diseases Laboratories Medical genetics Medical sciences Minority & ethnic groups Molecular and cellular biology Population short-report Single-nucleotide polymorphism Socioeconomic factors Tropical viral diseases Viral diseases Brazil Haiti Cleveland Ohio United States > US ethnicity race population structure DENV3 socioeconomic status Hemorrhagic fever Socioeconomic status Dengue hemorrhagic fever Dengue Population structure Ethnic group Infection Association Viral disease Arbovirus disease Race Genetics Population
ISSN:	1018-4813, 1476-5438
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Zusammenfassung:	To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF ( P =0.02, OR=0.28 and P =0.02, OR=0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1018-4813 1476-5438
DOI:	10.1038/ejhg.2008.4