Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional cytometry to analyze 125 COVID-19 patients and compare them with recovered and healthy individuals. Integrated analysis of ~200 immune and ~5...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 369; H. 6508
Hauptverfasser:	Mathew, Divij, Giles, Josephine R, Baxter, Amy E, Oldridge, Derek A, Greenplate, Allison R, Wu, Jennifer E, Alanio, Cécile, Kuri-Cervantes, Leticia, Pampena, M Betina, D'Andrea, Kurt, Manne, Sasikanth, Chen, Zeyu, Huang, Yinghui Jane, Reilly, John P, Weisman, Ariel R, Ittner, Caroline A G, Kuthuru, Oliva, Dougherty, Jeanette, Nzingha, Kito, Han, Nicholas, Kim, Justin, Pattekar, Ajinkya, Goodwin, Eileen C, Anderson, Elizabeth M, Weirick, Madison E, Gouma, Sigrid, Arevalo, Claudia P, Bolton, Marcus J, Chen, Fang, Lacey, Simon F, Ramage, Holly, Cherry, Sara, Hensley, Scott E, Apostolidis, Sokratis A, Huang, Alexander C, Vella, Laura A, Betts, Michael R, Meyer, Nuala J, Wherry, E John
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 04.09.2020
Schlagworte:	Adaptive Immunity Adult Aged Aged, 80 and over Antibodies, Viral - blood B-Lymphocyte Subsets - immunology B-Lymphocytes - immunology Betacoronavirus - immunology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Coronavirus Infections - immunology COVID-19 Cytokines - blood Female Humans Immunologic Memory Lymphocyte Activation Male Middle Aged Pandemics Plasma Cells - immunology Pneumonia, Viral - immunology SARS-CoV-2 Severity of Illness Index T-Lymphocyte Subsets - immunology T-Lymphocytes - immunology T-Lymphocytes, Helper-Inducer - immunology Time Factors Young Adult
ISSN:	1095-9203, 1095-9203
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