Selective laser sintering additive manufacturing of dosage forms: Effect of powder formulation and process parameters on the physical properties of printed tablets

[Display omitted] Large batches of placebo and drug-loaded solid dosage forms were successfully fabricated using selective laser sintering (SLS) 3D printing in this study. The tablet batches were prepared using either copovidone (N-vinyl-2-pyrrolidone and vinyl acetate, PVP/VA) or polyvinyl alcohol...

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Veröffentlicht in:International journal of pharmaceutics Jg. 635; S. 122780
Hauptverfasser: Tikhomirov, Evgenii, Åhlén, Michelle, Di Gallo, Nicole, Strømme, Maria, Kipping, Thomas, Quodbach, Julian, Lindh, Jonas
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 25.03.2023
Schlagworte:
Additive manufacturing
Dosage Forms
Drug Compounding - methods
Drug Liberation
Drug manufacturing
Engineering Science with specialization in Nanotechnology and Functional Materials
Lasers
Personalized medicines
Polymers - chemistry
Powders
Printing, Three-Dimensional
Selective laser sintering
Tablets - chemistry
Technology, Pharmaceutical - methods
Teknisk fysik med inriktning mot nanoteknologi och funktionella material
Three-dimensional printing
Drug manufacturing
Three-dimensional printing
Personalized medicines
Selective laser sintering
Additive manufacturing
ISSN:0378-5173, 1873-3476, 1873-3476
Online-Zugang:Volltext
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Zusammenfassung:[Display omitted] Large batches of placebo and drug-loaded solid dosage forms were successfully fabricated using selective laser sintering (SLS) 3D printing in this study. The tablet batches were prepared using either copovidone (N-vinyl-2-pyrrolidone and vinyl acetate, PVP/VA) or polyvinyl alcohol (PVA) and activated carbon (AC) as radiation absorbent, which was added to improve the sintering of the polymer. The physical properties of the dosage forms were evaluated at different pigment concentrations (i.e., 0.5 and 1.0 wt%) and at different laser energy inputs. The mass, hardness, and friability of the tablets were found to be tunable and structures with greater mass and mechanical strength were obtained with increasing carbon concentration and energy input. Amorphization of the active pharmaceutical ingredient in the drug-loaded batches, containing 10 wt% naproxen and 1 wt% AC, was achieved in-situ during printing. Thus, amorphous solid dispersions were prepared in a single-step process and produced tablets with mass losses below 1 wt%. These findings show how the properties of dosage forms can be tuned by careful selection of the process parameters and the powder formulation. SLS 3D printing can therefore be considered to be an interesting and promising technique for the fabrication of personalized medicines.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0378-5173
1873-3476
1873-3476
DOI:10.1016/j.ijpharm.2023.122780