Risk factors for carbapenem-resistant Enterobacteriaceae infections: a French case-control-control study

This study aimed to assess characteristics associated with infections due to carbapenem-resistant Enterobacteriaceae (CRE), producing (CPE) or not producing (non-CPE) carbapenemase, among hospitalised patients in 2014–2016 in France. Case-patients with CRE were compared to two control populations. I...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:European journal of clinical microbiology & infectious diseases Ročník 38; číslo 2; s. 383 - 393
Hlavní autoři: Nicolas-Chanoine, Marie-Hélène, Vigan, Marie, Laouénan, Cédric, Robert, Jérôme
Médium: Journal Article
Jazyk:angličtina
Vydáno: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2019
Springer Nature B.V
Springer Verlag
Témata:
Antibiotics
Biomedical and Life Sciences
Biomedicine
Carbapenemase
CRE bacteria
Enterobacteriaceae
Human health and pathology
Infections
Infectious diseases
Internal Medicine
Life Sciences
Mechanical ventilation
Medical Microbiology
Multivariate analysis
Original Article
Patients
Resistance factors
Risk analysis
Risk factors
Santé publique et épidémiologie
Urine
Ventilation
France
Multicentre study
Carbapenem-resistant Enterobacteriaceae (CRE)
Case-control-control study
Carbapenemase-producing Enterobacteriaceae (CPE)
Risk factors
ISSN:0934-9723, 1435-4373, 1435-4373
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:This study aimed to assess characteristics associated with infections due to carbapenem-resistant Enterobacteriaceae (CRE), producing (CPE) or not producing (non-CPE) carbapenemase, among hospitalised patients in 2014–2016 in France. Case-patients with CRE were compared to two control populations. In multivariate analysis comparing 160 CRE cases to 160 controls C1 (patients with a clinical sample positive for carbapenem-susceptible Enterobacteriaceae), five characteristics were linked to CRE: male gender (OR = 1.9; 95% CI = 1.3–3.4), travel in Asia (OR = 10.0; 95% CI = 1.1–91.2) and hospitalisation in (OR = 2.4; 95% CI = 1.3–4.4) or out of (OR = 4.4; 95% CI = 0.8–24.1) France in the preceding 12 months, infection in the preceding 3 months (OR = 3.0; 95% CI = 1.5–5.9), and antibiotic receipt between admission and inclusion (OR = 1.9; 95% CI = 1.0–3.3). In multivariate analysis comparing 148 CRE cases to 148 controls C2 [patients with culture-negative sample(s)], four characteristics were identified: prior infection (OR = 3.3; 95% CI = 1.6–6.8), urine drainage (OR = 3.0; 95% CI = 1.5–6.1) and mechanical ventilation (OR = 3.7; 95% CI = 1.1–13.0) during the current hospitalisation, and antibiotic receipt between admission and inclusion (OR = 6.6; 95% CI = 2.8–15.5). Univariate analyses comparing separately CPE cases to controls (39 CPE vs C1 and 36 CPE vs C2) and non-CPE cases to controls (121 non-CPE vs C1 and 112 non-CPE vs C2), concomitantly with comparison of CPE to non-CPE cases showed that only CPE cases were at risk of previous travel and hospitalisation abroad. This study shows that, among CRE, risk factors are different for CPE and non-CPE infection, and suggests that question patients about their medical history and lifestyle should help for early identification of patients at risk of CPE among patients with CRE.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0934-9723
1435-4373
1435-4373
DOI:10.1007/s10096-018-3438-9