Recent advances in the epithelial barrier theory

The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting the epithelial barrier. Global pollution and environmental toxic agent exposure have worsened over six decades because of uncontroll...

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Vydáno v:International immunology Ročník 36; číslo 5; s. 211 - 222
Hlavní autoři: Pat, Yagiz, Yazici, Duygu, D’Avino, Paolo, Li, Manru, Ardicli, Sena, Ardicli, Ozge, Mitamura, Yasutaka, Akdis, Mübeccel, Dhir, Raja, Nadeau, Kari, Agache, Ioana, Ogulur, Ismail, Akdis, Cezmi A
Médium: Journal Article
Jazyk:angličtina
Vydáno: UK Oxford University Press 03.04.2024
Témata:
Allergens
Epithelial Cells
Humans
Oxidative Stress
Particulate Matter - adverse effects
Tight Junctions
Vehicle Emissions - toxicity
particulate matter
pollution
exposome
detergents
ISSN:1460-2377, 1460-2377
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Shrnutí:The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting the epithelial barrier. Global pollution and environmental toxic agent exposure have worsened over six decades because of uncontrolled growth, modernization, and industrialization, affecting human health. Introducing new chemicals without any reasonable control of their health effects through these years has led to documented adverse effects, especially on the skin and mucosal epithelial barriers. These substances, such as particulate matter, detergents, surfactants, food emulsifiers, micro- and nano-plastics, diesel exhaust, cigarette smoke, and ozone, have been shown to compromise the epithelial barrier integrity. This disruption is linked to the opening of the tight-junction barriers, inflammation, cell death, oxidative stress, and metabolic regulation. Consideration must be given to the interplay of toxic substances, underlying inflammatory diseases, and medications, especially in affected tissues. This review article discusses the detrimental effect of environmental barrier-damaging compounds on human health and involves cellular and molecular mechanisms. Effects of environmental toxins on epithelial barrier functions Graphical Abstract Graphical Abstract
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ISSN:1460-2377
1460-2377
DOI:10.1093/intimm/dxae002