Assessing the robustness of dose distributions in carbon ion prostate radiotherapy using a fast dose evaluation system

Purpose We developed a software program for swiftly calculating dose distributions for carbon ion beams. This study aims to evaluate the accuracy of dose calculations using this software and assess the robustness of dose distribution in treating prostate cancer. Methods At the Osaka Heavy Ion Therap...

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Bibliographic Details
Published in:Journal of applied clinical medical physics Vol. 26; no. 1; pp. e14528 - n/a
Main Authors: Tsubouchi, Toshiro, Shiomi, Hiroya, Suzuki, Osamu, Hamatani, Noriaki, Takashina, Masaaki, Yagi, Masashi, Wakisaka, Yushi, Ogawa, Atsuhiro, Terasawa, Ayumi, Akino, Yuichi, Ogawa, Kazuhiko, Kanai, Tatsuaki
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01.01.2025
John Wiley and Sons Inc
Subjects:
Accuracy
adoptive therapy
bsPTV
Cancer therapies
Carbon
Carbon - therapeutic use
carbon ion radiotherapy
fast dose calculation
Heavy Ion Radiotherapy - methods
Humans
Male
Organs at Risk - radiation effects
Patients
Planning
Prostate cancer
Prostatic Neoplasms - radiotherapy
Radiation Oncology Physics
Radiation therapy
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy, Intensity-Modulated - methods
Software
X-rays
Japan
fast dose calculation
adoptive therapy
bsPTV
carbon ion radiotherapy
ISSN:1526-9914, 1526-9914
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Summary:Purpose We developed a software program for swiftly calculating dose distributions for carbon ion beams. This study aims to evaluate the accuracy of dose calculations using this software and assess the robustness of dose distribution in treating prostate cancer. Methods At the Osaka Heavy Ion Therapy Center, markers are inserted into the prostate gland and used for position verification. To account for geometric changes along the beam path due to marker translation, a beam‐specific planning target volume (bsPTV) is set for each beam. To validate the accuracy of the dose calculations using the developed software, dose distributions for prostate and sarcoma cases were calculated and compared with the treatment planning system. To assess the robustness of the dose distribution, position verification data from 346 cases were utilized to reproduce dose distributions for three matching methods: bone matching, widely adopted in most particle therapy centers; marker translation, which involves direct translation to markers without bone matching; and marker translation after bone matching. The coverage of the target (D99 of clinical target volume (CTV)) was assessed to evaluate the robustness of the dose distribution. Additionally, statistical analyses were conducted for the dose distributions of each matching method. Results The dose calculation for a single condition can be completed very quickly. Statistical analysis revealed significant differences among dose distributions considering the three matching methods. When irradiation was performed with bone matching only, the D99 was reduced by more than 10% in approximately 7.5% of cases, making it as the poorest among the three matching methods. However, there was no significant reduction in target coverage with the other two methods. Conclusion We have demonstrated the accuracy of the developed software for rapidly calculating dose distributions for carbon ion beams and confirmed the robustness of the dose distributions based on the bsPTV.
Bibliography:This study was approved by an institutional review board (Approval number: 240301).
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ISSN:1526-9914
1526-9914
DOI:10.1002/acm2.14528