A computer-aided approach to compare the production economics of fed-batch and perfusion culture under uncertainty

Fed‐batch and perfusion culture dominate mammalian cell culture production processes. In this paper, a decision‐support tool was employed to evaluate the economic feasibility of both culture modes via a case study based upon the large‐scale production of monoclonal antibodies. The trade‐offs between...

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Bibliographic Details
Published in:	Biotechnology and bioengineering Vol. 93; no. 4; pp. 687 - 697
Main Authors:	Lim, Ai Chye, Washbrook, John, Titchener-Hooker, Nigel John, Farid, Suzanne S.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 05.03.2006 Wiley Wiley Subscription Services, Inc
Subjects:	Antibodies, Monoclonal - economics Bacteriological Techniques Biological and medical sciences Bioreactors - economics Biotechnology Case studies cell culture Cells Computer Simulation computer-aided simulation Costs and Cost Analysis decision support Decision Support Techniques Economics Equipment Failure fed-batch Fouling Fundamental and applied biological sciences. Psychology Mammals Monte Carlo Method Monte Carlo simulation Nuclear polyhedrosis virus perfusion Perfusion - instrumentation process economics risk Technology, Pharmaceutical - economics uncertainty Biotechnology Cell culture Uncertainty perfusion Computer simulation Decision support system computer-aided simulation Monoclonal antibody decision support process economics fed-batch Animal Production risk Economic aspect Operating process Computer aid Semicontinuous
ISSN:	0006-3592, 1097-0290
Online Access:	Get full text
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