Expression of cAMP and oxidative phosphorylation‐related lncRNAs in non‐functioning pituitary adenomas

Non‐functioning pituitary adenomas (NFPAs) are benign lesions in the pituitary gland with important morbidities. In this study, based on a bioinformatics analysis to identify the genes and pathways that display significant differences between tumour tissues of NFPA patients and normal pituitary tiss...

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Vydané v:Journal of cellular and molecular medicine Ročník 27; číslo 24; s. 4195 - 4201
Hlavní autori: Taheri, Mohammad, Nicknam, Amir, Bagan, Atena, Eslami, Solat, Rakhshan, Azadeh, Ghafouri‐Fard, Soudeh
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England John Wiley & Sons, Inc 01.12.2023
John Wiley and Sons Inc
Predmet:
Adenoma
Bioinformatics
Biomarkers
cAMP
Cancer
Cyclic AMP
Gene expression
Hormones
lncRNA
Metabolism
Non-coding RNA
non‐functioning pituitary adenomas
Original
Oxidative phosphorylation
Phosphorylation
Pituitary
Signal transduction
Tumors
lncRNA
cAMP
non-functioning pituitary adenomas
oxidative phosphorylation
ISSN:1582-1838, 1582-4934, 1582-4934
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Popis
Shrnutí:Non‐functioning pituitary adenomas (NFPAs) are benign lesions in the pituitary gland with important morbidities. In this study, based on a bioinformatics analysis to identify the genes and pathways that display significant differences between tumour tissues of NFPA patients and normal pituitary tissues, we selected lncRNAs related to cAMP and oxidative phosphorylation pathways, namely DNAH17‐AS1, LINC00706 and SLC25A5‐AS1. Then, we aimed to investigate by means of RT‐qPCR, the expression of these lncRNAs along with two other lncRNAs, namely CADM3‐AS1 and MIR7‐3HG in NFPA samples compared to that in healthy tissues adjacent to the tumours. Transcripts of DNAH17‐AS1, LINC00706 and MIR7‐3HG were lower in NFPA samples compared with controls (Expression ratios (95% CI) = 0.43 (0.23–0.78), 0.58 (0.35–0.96) and 0.58 (0.35–0.96); p‐values = 0.009, 0.025 and 0.036, respectively). AUC values of ROC curves of DNAH17‐AS1, LINC00706 and MIR7‐3HG were 0.62, 0.61 and 0.62, respectively. Expression of CADM3‐AS1 was associated with the gender of patients in a way that it was lower in female patients (p‐value = 0.04). The level of SLC25A5‐AS1 was lower in subjects with disease duration lower than 1 year (p‐value = 0.048). We showed dysregulation of three lncRNAs in NFPA tissues and potentiates these lncRNAs as important regulators of pathogenic events in these tumours.
Bibliografia:ObjectType-Article-1
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ISSN:1582-1838
1582-4934
1582-4934
DOI:10.1111/jcmm.18011