Up‐regulation of HOXA‐AS2 and MEG3 long non‐coding RNAs acts as a potential peripheral biomarker for bipolar disorder

Bipolar disorder (BD) is a psychiatric condition that is frequently misdiagnosed and linked to inadequate treatment. Long non‐coding RNAs (lncRNAs) have lately gained recognition as crucial genetic elements and are now regarded as regulatory mechanisms in the neurological system. Our objective was t...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Journal of cellular and molecular medicine Ročník 28; číslo 21; s. e70150 - n/a
Hlavní autoři: Hosseini, Maryam, Mokhtari, Mohammad Javad
Médium: Journal Article
Jazyk:angličtina
Vydáno: England John Wiley & Sons, Inc 01.11.2024
John Wiley and Sons Inc
Témata:
Adult
biomarker
Biomarkers
Biomarkers - blood
Bipolar disorder
Bipolar Disorder - blood
Bipolar Disorder - diagnosis
Bipolar Disorder - genetics
Blood levels
Case-Control Studies
Correlation analysis
Education
Female
Gene expression
Gene Expression Regulation
Humans
LncRNA
Male
Marital status
MicroRNAs
MicroRNAs - blood
MicroRNAs - genetics
Middle Aged
Neural coding
Non-coding RNA
Original
Patients
Peripheral blood
real‐time PCR
RNA, Long Noncoding - blood
RNA, Long Noncoding - genetics
ROC Curve
Schizophrenia
Software
Thermal cycling
Up-Regulation - genetics
Iran
LncRNA
real‐time PCR
BD
biomarker
gene expression
ISSN:1582-1838, 1582-4934, 1582-4934
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Bipolar disorder (BD) is a psychiatric condition that is frequently misdiagnosed and linked to inadequate treatment. Long non‐coding RNAs (lncRNAs) have lately gained recognition as crucial genetic elements and are now regarded as regulatory mechanisms in the neurological system. Our objective was to measure the quantities of HOXA‐AS2 and MEG3 ncRNA transcripts. HOXA‐AS2 and MEG3 ncRNA levels were checked in the peripheral blood of 50 type I BD and 50 control samples by real‐time PCR. Furthermore, we conducted ROC curve analysis and correlation analysis to examine the association between gene expression and specific clinical characteristics in instances with BD. Additionally, a computational study was performed to investigate the binding sites of miRNAs on the HOXA‐AS2 and MEG3 lncRNAs. BD subjects showed a significant increase in the expression of HOXA‐AS2 and MEG3 compared to controls. The lncRNAs HOXA‐AS2 and MEG3 have an area under the ROC curve (AUC) values of 0.70 and 0.71, respectively. There was a significant correlation between the expression levels of ncRNAs HOXA‐AS2 and MEG3 in the peripheral blood of patients with BD and occupation scores. The data presented indicate a potential correlation between the expression of HOXA‐AS2 and MEG3 lncRNAs with an elevated risk of BD. Furthermore, these lncRNAs may be linked to several molecular pathways. Our findings indicate that the amounts of lncRNAs HOXA‐AS2 and MEG3 in transcripts might be a promising potential biomarker for patients with BD.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1582-1838
1582-4934
1582-4934
DOI:10.1111/jcmm.70150