FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway

The roles of fibronectin leucine-rich transmembrane protein 2 (FLRT2) in physiological and pathological processes are not well known. Here, we identify a potentially novel function of FLRT2 in preventing endothelial cell senescence and vascular aging. We found that FLRT2 expression was lower in cult...

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Bibliographic Details
Published in:	JCI insight Vol. 9; no. 7
Main Authors:	Hwang, Hyun Jung, Kang, Donghee, Kim, Jae-Ryong, Choi, Joon Hyuk, Ryu, Ji-Kan, Herman, Allison B., Ko, Young-Gyu, Park, Heon Joo, Gorospe, Myriam, Lee, Jae-Seon
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 08.04.2024 American Society for Clinical investigation
Subjects:	Aging AKT protein Animals Antibodies Cell biology Cell cycle Endothelial cells Endothelial Cells - metabolism Fibronectin Genotype & phenotype Humans Integrin beta4 - genetics Integrin beta4 - metabolism Kinases Mechanistic Target of Rapamycin Complex 2 - metabolism Membrane Glycoproteins - metabolism Mice Morphology p53 Protein Phenotypes Phosphorylation Proteins Rats Senescence Signal Transduction TOR protein Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Vascular biology Cell biology Vascular biology Cellular senescence
ISSN:	2379-3708, 2379-3708
Online Access:	Get full text
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