Identify Drug-Resistant Pathogens in Patients with Community-Acquired Pneumonia

A substantial increase in broad-spectrum antibiotics as empirical therapy in patients with community-acquired pneumonia (CAP) has occurred over the last 15 years. One of the driving factors leading to that has been some evidence showing an increased incidence of drug-resistant pathogens (DRP) in pat...

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Vydáno v:Advances in respiratory medicine Ročník 91; číslo 3; s. 224 - 238
Hlavní autoři: Amati, Francesco, Bindo, Francesco, Stainer, Anna, Gramegna, Andrea, Mantero, Marco, Nigro, Mattia, Bussini, Linda, Bartoletti, Michele, Blasi, Francesco, Aliberti, Stefano
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI 31.05.2023
MDPI AG
Témata:
broad-spectrum antibiotics
community-acquired pneumonia
drug-resistant pathogens
Review
community-acquired pneumonia
drug-resistant pathogens
broad-spectrum antibiotics
ISSN:2543-6031, 2451-4934, 2543-6031
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Shrnutí:A substantial increase in broad-spectrum antibiotics as empirical therapy in patients with community-acquired pneumonia (CAP) has occurred over the last 15 years. One of the driving factors leading to that has been some evidence showing an increased incidence of drug-resistant pathogens (DRP) in patients from a community with pneumonia, including methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Research has been published attempting to identify DRP in CAP through the implementation of probabilistic approaches in clinical practice. However, recent epidemiological data showed that the incidence of DRP in CAP varies significantly according to local ecology, healthcare systems and countries where the studies were performed. Several studies also questioned whether broad-spectrum antibiotic coverage might improve outcomes in CAP, as it is widely documented that broad-spectrum antibiotics overuse is associated with increased costs, length of hospital stay, drug adverse events and resistance. The aim of this review is to analyze the different approaches used to identify DRP in CAP patients as well as the outcomes and adverse events in patients undergoing broad-spectrum antibiotics.
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ISSN:2543-6031
2451-4934
2543-6031
DOI:10.3390/arm91030018