Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart

l-carnitine has been shown to play a central role in both fat and carbohydrate metabolisms. This study investigated whether acute and long-term treatments with an l-carnitine biosynthesis inhibitor, mildronate (3-(2,2,2-trimethylhydrazinium) propionate), modulate glucose uptake. The effects of acute...

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Veröffentlicht in:	Life sciences (1973) Jg. 83; H. 17; S. 613 - 619
Hauptverfasser:	Liepinsh, Edgars, Vilskersts, Reinis, Skapare, Elina, Svalbe, Baiba, Kuka, Janis, Cirule, Helena, Pugovics, Osvalds, Kalvinsh, Ivars, Dambrova, Maija
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Inc 24.10.2008
Schlagworte:	Animals Betaine - analogs & derivatives Betaine - analysis C-Peptide - analysis Cardiac energy metabolism Carnitine Carnitine - analysis Carnitine - metabolism Gene Expression Regulation - drug effects Glucose - metabolism Glucose Transporter Type 4 - genetics Glucose uptake Heart - drug effects Hexokinase - genetics Male Methylhydrazines - pharmacology Mice Mice, Inbred ICR Mildronate Myocardium - metabolism RNA, Messenger - analysis Up-Regulation FFA Cardiac energy metabolism HK II GLUT 4 INSR GBB PDC-E2 GLUT 1 PDC-E1 PDC Carnitine CPT IB LDH HDL Glucose uptake CPT IA FA Mildronate
ISSN:	0024-3205, 1879-0631
Online-Zugang:	Volltext
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