Obesity and triple‐negative‐breast‐cancer: Is apelin a new key target?

Epidemiological studies have shown that obese subjects have an increased risk of developing triple‐negative breast cancer (TNBC) and an overall reduced survival. However, the relation between obesity and TNBC remains difficult to understand. We hypothesize that apelin, an adipokine whose levels are...

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Vydáno v:	Journal of cellular and molecular medicine Ročník 24; číslo 17; s. 10233 - 10244
Hlavní autoři:	Gourgue, Florian, Mignion, Lionel, Van Hul, Matthias, Dehaen, Natacha, Bastien, Estelle, Payen, Valery, Leroy, Baptiste, Joudiou, Nicolas, Vertommen, Didier, Bouzin, Caroline, Delzenne, Nathalie, Gallez, Bernard, Feron, Olivier, Jordan, Bénédicte F., Cani, Patrice D.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England John Wiley & Sons, Inc 01.09.2020 John Wiley and Sons Inc
Témata:	Adipokines - metabolism Adipose tissue Adipose Tissue - metabolism Animals apelin Apelin - metabolism Brain cancer Brain Neoplasms - metabolism Brain Neoplasms - pathology Breast cancer Cell growth Cell Proliferation - physiology Diet Diet, High-Fat - adverse effects Epidemiology Experiments fat mass Female Gene expression High fat diet high‐fat Medical prognosis Metabolism Metastases Mice Mice, Inbred BALB C Mice, Inbred C57BL Neoplasm Metastasis - pathology Nitrogen NMR Nuclear magnetic resonance Obesity Obesity - metabolism Obesity - pathology obesity–cancer link Original Physiology Proteins RNA, Messenger - metabolism Subcutaneous Fat - metabolism Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology triple‐negative breast cancer Tumors United States > US Switzerland triple-negative breast cancer apelin obesity-cancer link high-fat fat mass
ISSN:	1582-1838, 1582-4934, 1582-4934
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Popis
Shrnutí:	Epidemiological studies have shown that obese subjects have an increased risk of developing triple‐negative breast cancer (TNBC) and an overall reduced survival. However, the relation between obesity and TNBC remains difficult to understand. We hypothesize that apelin, an adipokine whose levels are increased in obesity, could be a major factor contributing to both tumour growth and metastatization in TNBC obese patients. We observed that development of obesity under high‐fat diet in TNBC tumour‐bearing mice significantly increased tumour growth. By showing no effect of high‐fat diet in obesity‐resistant mice, we demonstrated the necessity to develop obesity‐related disorders to increase tumour growth. Apelin mRNA expression was also increased in the subcutaneous adipose tissue and tumours of obese mice. We further highlighted that the reproduction of obesity‐related levels of apelin in lean mice led to an increased TNBC growth and brain metastases formation. Finally, injections of the apelinergic antagonist F13A to obese mice significantly reduced TNBC growth, suggesting that apelinergic system interference could be an interesting therapeutic strategy in the context of obesity and TNBC.
Bibliografie:	Bénédicte F. Jordan and Patrice D. Cani, contributed equally to this work as last authors ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1582-1838 1582-4934 1582-4934
DOI:	10.1111/jcmm.15639