Obesity and triple‐negative‐breast‐cancer: Is apelin a new key target?

Epidemiological studies have shown that obese subjects have an increased risk of developing triple‐negative breast cancer (TNBC) and an overall reduced survival. However, the relation between obesity and TNBC remains difficult to understand. We hypothesize that apelin, an adipokine whose levels are...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine Vol. 24; no. 17; pp. 10233 - 10244
Main Authors: Gourgue, Florian, Mignion, Lionel, Van Hul, Matthias, Dehaen, Natacha, Bastien, Estelle, Payen, Valery, Leroy, Baptiste, Joudiou, Nicolas, Vertommen, Didier, Bouzin, Caroline, Delzenne, Nathalie, Gallez, Bernard, Feron, Olivier, Jordan, Bénédicte F., Cani, Patrice D.
Format: Journal Article
Language:English
Published: England John Wiley & Sons, Inc 01.09.2020
John Wiley and Sons Inc
Subjects:
Adipokines - metabolism
Adipose tissue
Adipose Tissue - metabolism
Animals
apelin
Apelin - metabolism
Brain cancer
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Breast cancer
Cell growth
Cell Proliferation - physiology
Diet
Diet, High-Fat - adverse effects
Epidemiology
Experiments
fat mass
Female
Gene expression
High fat diet
high‐fat
Medical prognosis
Metabolism
Metastases
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Neoplasm Metastasis - pathology
Nitrogen
NMR
Nuclear magnetic resonance
Obesity
Obesity - metabolism
Obesity - pathology
obesity–cancer link
Original
Physiology
Proteins
RNA, Messenger - metabolism
Subcutaneous Fat - metabolism
Triple Negative Breast Neoplasms - metabolism
Triple Negative Breast Neoplasms - pathology
triple‐negative breast cancer
Tumors
United States > US
Switzerland
triple-negative breast cancer
apelin
obesity-cancer link
high-fat
fat mass
ISSN:1582-1838, 1582-4934, 1582-4934
Online Access:Get full text
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Summary:Epidemiological studies have shown that obese subjects have an increased risk of developing triple‐negative breast cancer (TNBC) and an overall reduced survival. However, the relation between obesity and TNBC remains difficult to understand. We hypothesize that apelin, an adipokine whose levels are increased in obesity, could be a major factor contributing to both tumour growth and metastatization in TNBC obese patients. We observed that development of obesity under high‐fat diet in TNBC tumour‐bearing mice significantly increased tumour growth. By showing no effect of high‐fat diet in obesity‐resistant mice, we demonstrated the necessity to develop obesity‐related disorders to increase tumour growth. Apelin mRNA expression was also increased in the subcutaneous adipose tissue and tumours of obese mice. We further highlighted that the reproduction of obesity‐related levels of apelin in lean mice led to an increased TNBC growth and brain metastases formation. Finally, injections of the apelinergic antagonist F13A to obese mice significantly reduced TNBC growth, suggesting that apelinergic system interference could be an interesting therapeutic strategy in the context of obesity and TNBC.
Bibliography:Bénédicte F. Jordan and Patrice D. Cani, contributed equally to this work as last authors
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ISSN:1582-1838
1582-4934
1582-4934
DOI:10.1111/jcmm.15639