Obesity and triple‐negative‐breast‐cancer: Is apelin a new key target?

Epidemiological studies have shown that obese subjects have an increased risk of developing triple‐negative breast cancer (TNBC) and an overall reduced survival. However, the relation between obesity and TNBC remains difficult to understand. We hypothesize that apelin, an adipokine whose levels are...

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Bibliographic Details
Published in:	Journal of cellular and molecular medicine Vol. 24; no. 17; pp. 10233 - 10244
Main Authors:	Gourgue, Florian, Mignion, Lionel, Van Hul, Matthias, Dehaen, Natacha, Bastien, Estelle, Payen, Valery, Leroy, Baptiste, Joudiou, Nicolas, Vertommen, Didier, Bouzin, Caroline, Delzenne, Nathalie, Gallez, Bernard, Feron, Olivier, Jordan, Bénédicte F., Cani, Patrice D.
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.09.2020 John Wiley and Sons Inc
Subjects:	Adipokines - metabolism Adipose tissue Adipose Tissue - metabolism Animals apelin Apelin - metabolism Brain cancer Brain Neoplasms - metabolism Brain Neoplasms - pathology Breast cancer Cell growth Cell Proliferation - physiology Diet Diet, High-Fat - adverse effects Epidemiology Experiments fat mass Female Gene expression High fat diet high‐fat Medical prognosis Metabolism Metastases Mice Mice, Inbred BALB C Mice, Inbred C57BL Neoplasm Metastasis - pathology Nitrogen NMR Nuclear magnetic resonance Obesity Obesity - metabolism Obesity - pathology obesity–cancer link Original Physiology Proteins RNA, Messenger - metabolism Subcutaneous Fat - metabolism Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology triple‐negative breast cancer Tumors United States > US Switzerland triple-negative breast cancer apelin obesity-cancer link high-fat fat mass
ISSN:	1582-1838, 1582-4934, 1582-4934
Online Access:	Get full text
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