Diabetic ketoacidosis at diagnosis among youth with type 1 and type 2 diabetes: Results from SEARCH (United States) and YDR (India) registries

Background There is significant global variation in the prevalence of diabetic ketoacidosis (DKA) at diagnosis among youth with type 1 diabetes (T1D). However, data for youth with type 2 diabetes (T2D) are limited, even in developed countries. We compared the prevalence of DKA at diagnosis among ind...

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Veröffentlicht in:Pediatric diabetes Jg. 22; H. 1; S. 40 - 46
Hauptverfasser: Praveen, Pradeep A., Hockett, Christine W., Ong, Toan C., Amutha, Anandakumar, Isom, Scott P., Jensen, Elizabeth T., Mohan, Viswanathan, Dabelea, Dana A., D'Agostino, Ralph B., Hamman, Richard F., Mayer‐Davis, Elizabeth J., Lawrence, Jean M., Dolan, Lawrence M., Kahn, Michael G., Madhu, Sri Venkata, Tandon, Nikhil
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Former Munksgaard John Wiley & Sons A/S 01.02.2021
John Wiley & Sons, Inc
Schlagworte:
Adolescent
Child
Child, Preschool
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 1 - diagnosis
Diabetes Mellitus, Type 2 - diagnosis
Diabetic ketoacidosis
Diabetic Ketoacidosis - epidemiology
Diagnosis
Female
Humans
India - epidemiology
Infant
Infant, Newborn
Ketoacidosis
Male
Medical diagnosis
Registries
SEARCH for Diabetes in Youth registry
Terminology
type 1 diabetes
type 2 diabetes
United States - epidemiology
YDR registry
Young Adult
United States
India
United States > US
type 1 diabetes
SEARCH for Diabetes in Youth registry
type 2 diabetes
YDR registry
diabetic ketoacidosis
ISSN:1399-543X, 1399-5448, 1399-5448
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Zusammenfassung:Background There is significant global variation in the prevalence of diabetic ketoacidosis (DKA) at diagnosis among youth with type 1 diabetes (T1D). However, data for youth with type 2 diabetes (T2D) are limited, even in developed countries. We compared the prevalence of DKA at diagnosis among individuals with T1D and T2D from the SEARCH for Diabetes in Youth (SEARCH) and the Registry of Youth Onset Diabetes in India (YDR) registries. Methods We harmonized the SEARCH and YDR registries to the structure and terminology in the Observational Medical Outcome Partnership Common Data Model. Data used were from youth with T1D and T2D diagnosed before 20 years and newly diagnosed between 2006 and 2012 in YDR and 2009 and 2012 in SEARCH. Results There were 5366 US youth (4078 with T1D, 1288 with T2D) and 2335 Indian youth (2108 with T1D, 227 with T2D). More than one third of T1D youth enrolled in SEARCH had DKA at diagnosis which was significantly higher than in YDR (35.3% vs 28.7%, P < .0001). The burden of DKA in youth with T1D was significantly higher among younger age groups; this relationship was similar across registries (P = .4). The prevalence of DKA among T2D in SEARCH and YDR were 5.5% and 6.6% respectively (P = .4). Conclusions There is significant burden of DKA at diagnosis with T1D among youth from United States and India, especially among the younger age groups. The reasons for this high prevalence are largely unknown but are critical to developing interventions to prevent DKA at diagnosis.
Bibliographie:Funding information
Wake Forest University School of Medicine, Grant/Award Numbers: 200‐2010‐35171, U01 DP000250, U48/CCU919219, U18DP006131; Seattle Children's Hospital, Grant/Award Numbers: U18DP002710‐01, U01 DP000244, U58/CCU019235‐4, U18DP006136; University of North Carolina at Chapel Hill, Grant/Award Numbers: U18DP002708, U01 DP000254, U48/CCU419249, U18DP006138; Cincinnati's Children's Hospital Medical Center, Grant/Award Numbers: 1U18DP002709, U01 DP000248, U48/CCU519239, U18DP006134; University of Colorado Denver, Grant/Award Numbers: U18DP000247‐06A1, U01 DP000247, U48/CCU819241‐3, U18DP006139; Kaiser Permanente Southern California, Grant/Award Numbers: U18DP002714, U01 DP000246, U48/CCU919219, U18DP006133; Centers for Disease Control and Prevention, Grant/Award Numbers: U18DP006139, U18DP006138, U18DP006136, U18DP006134, U18DP006133, 1U18DP006131, DP‐10‐001, DP‐05‐069, 00097; National Institute of Diabetes and Digestive and Kidney Diseases; Ohio Department of Health; University of Cincinnati, NIH/NCATS, Grant/Award Numbers: UL1 TR001425, UL1 TR000077; University of Colorado at Denver, Grant/Award Number: P30 DK57516; University of Colorado Pediatric Clinical and Translational Research Center, NIH/NCATS, Grant/Award Number: UL1 TR000154; Seattle Children's Hospital and the University of Washington, NIH/NCATS, Grant/Award Number: UL1 TR00423; Medical University of South Carolina, NIH/National Center for Advancing Translational Sciences (NCATS), Grant/Award Numbers: UL1 Tr001450, UL1 TR000062; Southern California Permanente Medical Group; Kaiser Foundation Health Plan; Indian Council of Medical Research; National Institutes of Health, Grant/Award Number: R21DK105869‐02
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Author contributions: N.T, D.D, V.M, R.F.H and E.J.M.-D conceptualized the study and oversaw the data harmonization. T.C.O, M.G.K, C.W.H, S.P.I., A.A and P.P harmonized and transformed data into the common data model (OMOP). S.P.I., C.W.H and T.C.O conducted data analysis. P.P and N.T prepared the first draft of the manuscript and provided oversight for study analyses. S.V.M contributed to data collection. All authors reviewed and edited the manuscript and contributed to discussion. All authors have read and approved the final manuscript.
ISSN:1399-543X
1399-5448
1399-5448
DOI:10.1111/pedi.12979