Contribution of adiponectin polymorphisms to the risk of coronary artery disease in a North‐African Tunisian population

Background Adiponectin, an adipocyte‐derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD) through its anti‐atherogenic, anti‐inflammatory, antioxidative, and anti‐apoptotic properties. In the current study, we have studied the ass...

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Vydáno v:	Journal of clinical laboratory analysis Ročník 32; číslo 7; s. e22446 - n/a
Hlavní autoři:	Ghazouani, Lakhdar, Elmufti, Afoua, Baaziz, Intissar, Chaabane, Ibtissem, Ben Mansour, Hedi
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States John Wiley & Sons, Inc 01.09.2018 John Wiley and Sons Inc
Témata:	Adiponectin Adiponectin - genetics African Continental Ancestry Group - genetics Aged Apoptosis Arteriosclerosis Cardiovascular disease Case-Control Studies Coronary artery coronary artery disease Coronary Artery Disease - epidemiology Coronary Artery Disease - genetics Coronary vessels Female Gene polymorphism genetic association Genetic Association Studies Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics haplotype Haplotypes Heart diseases Humans Inflammation Male Middle Aged Polymerase chain reaction Polymorphism Polymorphism, Single Nucleotide - genetics Regression analysis Restriction fragment length polymorphism Risk factors Single-nucleotide polymorphism Tunisia - epidemiology coronary artery disease genetic association adiponectin haplotype single nucleotide polymorphism
ISSN:	0887-8013, 1098-2825, 1098-2825
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Abstract	Background Adiponectin, an adipocyte‐derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD) through its anti‐atherogenic, anti‐inflammatory, antioxidative, and anti‐apoptotic properties. In the current study, we have studied the association of two single nucleotide polymorphisms (SNPs) +45 T>G (rs2241766) and +276 G>T (rs1501299) of the adiponectin gene with coronary artery disease (CAD) on an Arab/North‐African population from Tunisia. Methods Subjects comprised 277 patients with angiographically demonstrated CAD and 269 age‐ and gender‐matched control subjects. The adiponectin genotypes were performed by polymerase chain reaction‐restriction fragment length polymorphism analysis (PCR‐RFLP). The contribution of adiponectin variants to CAD was analyzed by haplotype and regression analysis. Results Adiponectin +45T>G and +276G>T genotypic and allelic distributions did not show a significant difference between cases and controls. Similarly, no association with CAD was observed for the haplotype analysis. Assuming dominant model of transmission for both polymorphisms and after adjustment of a number of traditional risk factors for CAD, logistic regression analysis showed an association of SNP +45 T>G with increased risk of developing CAD [adjusted OR (95% CI) = 2.59 (1.17‐5.70); P = .01]. However, SNP + 276 G>T is associated with decreased risk of developing CAD [adjusted OR (95% CI) = 0.47 (0.22‐0.97); P = .04]. Conclusion There is no allelic or genotypic association of +45 T>G and +276 G>T of the adiponectin gene with CAD in the Tunisian population.
AbstractList	Adiponectin, an adipocyte-derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD) through its anti-atherogenic, anti-inflammatory, antioxidative, and anti-apoptotic properties. In the current study, we have studied the association of two single nucleotide polymorphisms (SNPs) +45 T>G (rs2241766) and +276 G>T (rs1501299) of the adiponectin gene with coronary artery disease (CAD) on an Arab/North-African population from Tunisia.BACKGROUNDAdiponectin, an adipocyte-derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD) through its anti-atherogenic, anti-inflammatory, antioxidative, and anti-apoptotic properties. In the current study, we have studied the association of two single nucleotide polymorphisms (SNPs) +45 T>G (rs2241766) and +276 G>T (rs1501299) of the adiponectin gene with coronary artery disease (CAD) on an Arab/North-African population from Tunisia.Subjects comprised 277 patients with angiographically demonstrated CAD and 269 age- and gender-matched control subjects. The adiponectin genotypes were performed by polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP). The contribution of adiponectin variants to CAD was analyzed by haplotype and regression analysis.METHODSSubjects comprised 277 patients with angiographically demonstrated CAD and 269 age- and gender-matched control subjects. The adiponectin genotypes were performed by polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP). The contribution of adiponectin variants to CAD was analyzed by haplotype and regression analysis.Adiponectin +45T>G and +276G>T genotypic and allelic distributions did not show a significant difference between cases and controls. Similarly, no association with CAD was observed for the haplotype analysis. Assuming dominant model of transmission for both polymorphisms and after adjustment of a number of traditional risk factors for CAD, logistic regression analysis showed an association of SNP +45 T>G with increased risk of developing CAD [adjusted OR (95% CI) = 2.59 (1.17-5.70); P = .01]. However, SNP + 276 G>T is associated with decreased risk of developing CAD [adjusted OR (95% CI) = 0.47 (0.22-0.97); P = .04].RESULTSAdiponectin +45T>G and +276G>T genotypic and allelic distributions did not show a significant difference between cases and controls. Similarly, no association with CAD was observed for the haplotype analysis. Assuming dominant model of transmission for both polymorphisms and after adjustment of a number of traditional risk factors for CAD, logistic regression analysis showed an association of SNP +45 T>G with increased risk of developing CAD [adjusted OR (95% CI) = 2.59 (1.17-5.70); P = .01]. However, SNP + 276 G>T is associated with decreased risk of developing CAD [adjusted OR (95% CI) = 0.47 (0.22-0.97); P = .04].There is no allelic or genotypic association of +45 T>G and +276 G>T of the adiponectin gene with CAD in the Tunisian population.CONCLUSIONThere is no allelic or genotypic association of +45 T>G and +276 G>T of the adiponectin gene with CAD in the Tunisian population. BackgroundAdiponectin, an adipocyte‐derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD) through its anti‐atherogenic, anti‐inflammatory, antioxidative, and anti‐apoptotic properties. In the current study, we have studied the association of two single nucleotide polymorphisms (SNPs) +45 T>G (rs2241766) and +276 G>T (rs1501299) of the adiponectin gene with coronary artery disease (CAD) on an Arab/North‐African population from Tunisia.MethodsSubjects comprised 277 patients with angiographically demonstrated CAD and 269 age‐ and gender‐matched control subjects. The adiponectin genotypes were performed by polymerase chain reaction‐restriction fragment length polymorphism analysis (PCR‐RFLP). The contribution of adiponectin variants to CAD was analyzed by haplotype and regression analysis.ResultsAdiponectin +45T>G and +276G>T genotypic and allelic distributions did not show a significant difference between cases and controls. Similarly, no association with CAD was observed for the haplotype analysis. Assuming dominant model of transmission for both polymorphisms and after adjustment of a number of traditional risk factors for CAD, logistic regression analysis showed an association of SNP +45 T>G with increased risk of developing CAD [adjusted OR (95% CI) = 2.59 (1.17‐5.70); P = .01]. However, SNP + 276 G>T is associated with decreased risk of developing CAD [adjusted OR (95% CI) = 0.47 (0.22‐0.97); P = .04].ConclusionThere is no allelic or genotypic association of +45 T>G and +276 G>T of the adiponectin gene with CAD in the Tunisian population. Background Adiponectin, an adipocyte‐derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD) through its anti‐atherogenic, anti‐inflammatory, antioxidative, and anti‐apoptotic properties. In the current study, we have studied the association of two single nucleotide polymorphisms (SNPs) +45 T>G (rs2241766) and +276 G>T (rs1501299) of the adiponectin gene with coronary artery disease (CAD) on an Arab/North‐African population from Tunisia. Methods Subjects comprised 277 patients with angiographically demonstrated CAD and 269 age‐ and gender‐matched control subjects. The adiponectin genotypes were performed by polymerase chain reaction‐restriction fragment length polymorphism analysis (PCR‐RFLP). The contribution of adiponectin variants to CAD was analyzed by haplotype and regression analysis. Results Adiponectin +45T>G and +276G>T genotypic and allelic distributions did not show a significant difference between cases and controls. Similarly, no association with CAD was observed for the haplotype analysis. Assuming dominant model of transmission for both polymorphisms and after adjustment of a number of traditional risk factors for CAD, logistic regression analysis showed an association of SNP +45 T>G with increased risk of developing CAD [adjusted OR (95% CI) = 2.59 (1.17‐5.70); P = .01]. However, SNP + 276 G>T is associated with decreased risk of developing CAD [adjusted OR (95% CI) = 0.47 (0.22‐0.97); P = .04]. Conclusion There is no allelic or genotypic association of +45 T>G and +276 G>T of the adiponectin gene with CAD in the Tunisian population. Adiponectin, an adipocyte-derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD) through its anti-atherogenic, anti-inflammatory, antioxidative, and anti-apoptotic properties. In the current study, we have studied the association of two single nucleotide polymorphisms (SNPs) +45 T>G (rs2241766) and +276 G>T (rs1501299) of the adiponectin gene with coronary artery disease (CAD) on an Arab/North-African population from Tunisia. Subjects comprised 277 patients with angiographically demonstrated CAD and 269 age- and gender-matched control subjects. The adiponectin genotypes were performed by polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP). The contribution of adiponectin variants to CAD was analyzed by haplotype and regression analysis. Adiponectin +45T>G and +276G>T genotypic and allelic distributions did not show a significant difference between cases and controls. Similarly, no association with CAD was observed for the haplotype analysis. Assuming dominant model of transmission for both polymorphisms and after adjustment of a number of traditional risk factors for CAD, logistic regression analysis showed an association of SNP +45 T>G with increased risk of developing CAD [adjusted OR (95% CI) = 2.59 (1.17-5.70); P = .01]. However, SNP + 276 G>T is associated with decreased risk of developing CAD [adjusted OR (95% CI) = 0.47 (0.22-0.97); P = .04]. There is no allelic or genotypic association of +45 T>G and +276 G>T of the adiponectin gene with CAD in the Tunisian population.
Author	Ghazouani, Lakhdar Baaziz, Intissar Ben Mansour, Hedi Elmufti, Afoua Chaabane, Ibtissem
AuthorAffiliation	1 Research Unit of Macromolecular Biochemistry and Genetics Faculty of Sciences of Gafsa Gafsa Tunisia 2 Research Unit of Analysis and Process Applied to the Environmental–APAE (UR17ES32) Higher Institute of Applied Sciences and Technology Mahdia University of Monastir Monastir Tunisia
AuthorAffiliation_xml	– name: 2 Research Unit of Analysis and Process Applied to the Environmental–APAE (UR17ES32) Higher Institute of Applied Sciences and Technology Mahdia University of Monastir Monastir Tunisia – name: 1 Research Unit of Macromolecular Biochemistry and Genetics Faculty of Sciences of Gafsa Gafsa Tunisia
Author_xml	– sequence: 1 givenname: Lakhdar orcidid: 0000-0001-7457-9113 surname: Ghazouani fullname: Ghazouani, Lakhdar email: ghazouani2005@yahoo.fr organization: Faculty of Sciences of Gafsa – sequence: 2 givenname: Afoua surname: Elmufti fullname: Elmufti, Afoua organization: Faculty of Sciences of Gafsa – sequence: 3 givenname: Intissar surname: Baaziz fullname: Baaziz, Intissar organization: Faculty of Sciences of Gafsa – sequence: 4 givenname: Ibtissem surname: Chaabane fullname: Chaabane, Ibtissem organization: Faculty of Sciences of Gafsa – sequence: 5 givenname: Hedi surname: Ben Mansour fullname: Ben Mansour, Hedi organization: University of Monastir
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CitedBy_id	crossref_primary_10_1016_j_cyto_2024_156567 crossref_primary_10_1016_j_fsi_2019_04_045 crossref_primary_10_2147_TACG_S282843 crossref_primary_10_1016_j_genrep_2018_11_007 crossref_primary_10_1155_2020_3176521
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Snippet	Background Adiponectin, an adipocyte‐derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD)... Adiponectin, an adipocyte-derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD) through... BackgroundAdiponectin, an adipocyte‐derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD)...
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SubjectTerms	Adiponectin Adiponectin - genetics African Continental Ancestry Group - genetics Aged Apoptosis Arteriosclerosis Cardiovascular disease Case-Control Studies Coronary artery coronary artery disease Coronary Artery Disease - epidemiology Coronary Artery Disease - genetics Coronary vessels Female Gene polymorphism genetic association Genetic Association Studies Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics haplotype Haplotypes Heart diseases Humans Inflammation Male Middle Aged Polymerase chain reaction Polymorphism Polymorphism, Single Nucleotide - genetics Regression analysis Restriction fragment length polymorphism Risk factors Single-nucleotide polymorphism Tunisia - epidemiology
Title	Contribution of adiponectin polymorphisms to the risk of coronary artery disease in a North‐African Tunisian population
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