Contribution of adiponectin polymorphisms to the risk of coronary artery disease in a North‐African Tunisian population

Background Adiponectin, an adipocyte‐derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD) through its anti‐atherogenic, anti‐inflammatory, antioxidative, and anti‐apoptotic properties. In the current study, we have studied the ass...

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Veröffentlicht in:Journal of clinical laboratory analysis Jg. 32; H. 7; S. e22446 - n/a
Hauptverfasser: Ghazouani, Lakhdar, Elmufti, Afoua, Baaziz, Intissar, Chaabane, Ibtissem, Ben Mansour, Hedi
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States John Wiley & Sons, Inc 01.09.2018
John Wiley and Sons Inc
Schlagworte:
Adiponectin
Adiponectin - genetics
African Continental Ancestry Group - genetics
Aged
Apoptosis
Arteriosclerosis
Cardiovascular disease
Case-Control Studies
Coronary artery
coronary artery disease
Coronary Artery Disease - epidemiology
Coronary Artery Disease - genetics
Coronary vessels
Female
Gene polymorphism
genetic association
Genetic Association Studies
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - genetics
haplotype
Haplotypes
Heart diseases
Humans
Inflammation
Male
Middle Aged
Polymerase chain reaction
Polymorphism
Polymorphism, Single Nucleotide - genetics
Regression analysis
Restriction fragment length polymorphism
Risk factors
Single-nucleotide polymorphism
Tunisia - epidemiology
coronary artery disease
genetic association
adiponectin
haplotype
single nucleotide polymorphism
ISSN:0887-8013, 1098-2825, 1098-2825
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Zusammenfassung:Background Adiponectin, an adipocyte‐derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD) through its anti‐atherogenic, anti‐inflammatory, antioxidative, and anti‐apoptotic properties. In the current study, we have studied the association of two single nucleotide polymorphisms (SNPs) +45 T>G (rs2241766) and +276 G>T (rs1501299) of the adiponectin gene with coronary artery disease (CAD) on an Arab/North‐African population from Tunisia. Methods Subjects comprised 277 patients with angiographically demonstrated CAD and 269 age‐ and gender‐matched control subjects. The adiponectin genotypes were performed by polymerase chain reaction‐restriction fragment length polymorphism analysis (PCR‐RFLP). The contribution of adiponectin variants to CAD was analyzed by haplotype and regression analysis. Results Adiponectin +45T>G and +276G>T genotypic and allelic distributions did not show a significant difference between cases and controls. Similarly, no association with CAD was observed for the haplotype analysis. Assuming dominant model of transmission for both polymorphisms and after adjustment of a number of traditional risk factors for CAD, logistic regression analysis showed an association of SNP +45 T>G with increased risk of developing CAD [adjusted OR (95% CI) = 2.59 (1.17‐5.70); P = .01]. However, SNP + 276 G>T is associated with decreased risk of developing CAD [adjusted OR (95% CI) = 0.47 (0.22‐0.97); P = .04]. Conclusion There is no allelic or genotypic association of +45 T>G and +276 G>T of the adiponectin gene with CAD in the Tunisian population.
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ISSN:0887-8013
1098-2825
1098-2825
DOI:10.1002/jcla.22446