The role of regional anaesthesia and multimodal analgesia in the prevention of chronic postoperative pain: a narrative review

Summary Effective prevention of chronic postoperative pain is an important clinical goal, informed by a growing body of studies. Peri‐operative regional anaesthesia remains one of the most important tools in the multimodal analgesic toolbox, blocking injury‐induced activation and sensitisation of bo...

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Published in:Anaesthesia Vol. 76; no. S1; pp. 8 - 17
Main Authors: Chen, Y.‐Y. K., Boden, K. A., Schreiber, K. L.
Format: Journal Article
Language:English
Published: England Blackwell Publishing Ltd 01.01.2021
Subjects:
Analgesia
Analgesia - methods
Analgesics
Anesthesia
Anesthesia, Conduction - methods
Central nervous system
Chronic Pain - prevention & control
chronic postoperative pain
Heterogeneity
Humans
multimodal analgesia
Pain
Pain Management - methods
Pain perception
Pain, Postoperative - prevention & control
Postoperative period
Prevention
regional anaesthesia
Regional anesthesia
Risk assessment
Risk Factors
Taxonomy
chronic postoperative pain
regional anaesthesia
multimodal analgesia
ISSN:0003-2409, 1365-2044, 1365-2044
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Abstract Summary Effective prevention of chronic postoperative pain is an important clinical goal, informed by a growing body of studies. Peri‐operative regional anaesthesia remains one of the most important tools in the multimodal analgesic toolbox, blocking injury‐induced activation and sensitisation of both the peripheral and central nervous system. We review the definition and taxonomy of chronic postoperative pain, its mechanistic basis and the most recent evidence for the preventative potential of multimodal analgesia, with a special focus on regional anaesthesia. While regional anaesthesia targets several important aspects of the mechanistic pathway leading to chronic postoperative pain, evidence for its efficacy is still mixed, possibly owing to the heterogeneity of risk profiles within the surgical patient, but also to variation in techniques and medications reported in the literature.
AbstractList Effective prevention of chronic postoperative pain is an important clinical goal, informed by a growing body of studies. Peri-operative regional anaesthesia remains one of the most important tools in the multimodal analgesic toolbox, blocking injury-induced activation and sensitisation of both the peripheral and central nervous system. We review the definition and taxonomy of chronic postoperative pain, its mechanistic basis and the most recent evidence for the preventative potential of multimodal analgesia, with a special focus on regional anaesthesia. While regional anaesthesia targets several important aspects of the mechanistic pathway leading to chronic postoperative pain, evidence for its efficacy is still mixed, possibly owing to the heterogeneity of risk profiles within the surgical patient, but also to variation in techniques and medications reported in the literature.
Effective prevention of chronic postoperative pain is an important clinical goal, informed by a growing body of studies. Peri-operative regional anaesthesia remains one of the most important tools in the multimodal analgesic toolbox, blocking injury-induced activation and sensitisation of both the peripheral and central nervous system. We review the definition and taxonomy of chronic postoperative pain, its mechanistic basis and the most recent evidence for the preventative potential of multimodal analgesia, with a special focus on regional anaesthesia. While regional anaesthesia targets several important aspects of the mechanistic pathway leading to chronic postoperative pain, evidence for its efficacy is still mixed, possibly owing to the heterogeneity of risk profiles within the surgical patient, but also to variation in techniques and medications reported in the literature.Effective prevention of chronic postoperative pain is an important clinical goal, informed by a growing body of studies. Peri-operative regional anaesthesia remains one of the most important tools in the multimodal analgesic toolbox, blocking injury-induced activation and sensitisation of both the peripheral and central nervous system. We review the definition and taxonomy of chronic postoperative pain, its mechanistic basis and the most recent evidence for the preventative potential of multimodal analgesia, with a special focus on regional anaesthesia. While regional anaesthesia targets several important aspects of the mechanistic pathway leading to chronic postoperative pain, evidence for its efficacy is still mixed, possibly owing to the heterogeneity of risk profiles within the surgical patient, but also to variation in techniques and medications reported in the literature.
Summary Effective prevention of chronic postoperative pain is an important clinical goal, informed by a growing body of studies. Peri‐operative regional anaesthesia remains one of the most important tools in the multimodal analgesic toolbox, blocking injury‐induced activation and sensitisation of both the peripheral and central nervous system. We review the definition and taxonomy of chronic postoperative pain, its mechanistic basis and the most recent evidence for the preventative potential of multimodal analgesia, with a special focus on regional anaesthesia. While regional anaesthesia targets several important aspects of the mechanistic pathway leading to chronic postoperative pain, evidence for its efficacy is still mixed, possibly owing to the heterogeneity of risk profiles within the surgical patient, but also to variation in techniques and medications reported in the literature.
Author Schreiber, K. L.
Boden, K. A.
Chen, Y.‐Y. K.
AuthorAffiliation 1 Regional Anaesthesia and Acute Pain Medicine Fellow, Brigham and Women’s Hospital, Boston, MA, USA
2 Anaesthesia Resident, Brigham and Women’s Hospital, Boston, MA, USA
3 Department of Anesthesiology, Peri-operative and Pain Medicine, Brigham and Women’s Hospital, Boston, MA, USA
AuthorAffiliation_xml – name: 1 Regional Anaesthesia and Acute Pain Medicine Fellow, Brigham and Women’s Hospital, Boston, MA, USA
– name: 2 Anaesthesia Resident, Brigham and Women’s Hospital, Boston, MA, USA
– name: 3 Department of Anesthesiology, Peri-operative and Pain Medicine, Brigham and Women’s Hospital, Boston, MA, USA
Author_xml – sequence: 1
  givenname: Y.‐Y. K.
  orcidid: 0000-0002-3770-2749
  surname: Chen
  fullname: Chen, Y.‐Y. K.
  email: ykchen@partners.org
  organization: Brigham and Women's Hospital
– sequence: 2
  givenname: K. A.
  surname: Boden
  fullname: Boden, K. A.
  organization: Brigham and Women's Hospital
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  givenname: K. L.
  orcidid: 0000-0002-7361-2214
  surname: Schreiber
  fullname: Schreiber, K. L.
  organization: Brigham and Women's Hospital
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33426669$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1093/pm/pny099
10.1124/jpet.300.1.282
10.1371/journal.pone.0152741
10.1016/j.neuron.2007.07.016
10.3344/kjp.2018.31.3.155
10.1016/j.jpain.2019.08.008
10.1097/j.pain.0000000000001273
10.3390/jcm9030793
10.1136/bmj.g1251
10.1097/00002508-199603000-00009
10.1136/postgradmedj-2013-132215
10.4103/0973-1075.97354
10.1097/j.pain.0000000000001413
10.1097/01.sla.0000245495.79781.65
10.1016/j.sjpain.2014.12.005
10.1016/0304-3959(88)90286-2
10.1111/papr.12615
10.1097/PR9.0000000000000627
10.1097/AAP.0000000000000564
10.1586/ern.09.20
10.1111/papr.12442
10.1097/MD.0000000000011181
10.1007/s11916-020-00853-z
10.1016/0304-3959(91)90100-C
10.1016/j.ijsu.2019.02.007
10.1016/j.bja.2019.06.014
10.2217/pmt.14.33
10.1111/anae.14856
10.1093/bja/87.1.88
10.1016/S0140-6736(06)68700-X
10.1097/j.pain.0000000000001433
10.1111/j.1399-6576.2004.00271.x
10.1097/AJP.0000000000000317
10.1007/s11916-018-0666-8
10.1038/nrdp.2017.2
10.1093/bja/aeu012
10.1097/01.aco.0000432511.08070.de
10.1016/j.pain.2010.09.030
10.1146/annurev.neuro.051508.135531
10.1038/35093019
10.1016/j.bja.2019.01.041
10.1016/j.jpain.2014.01.004
10.1097/ALN.0000000000002238
10.1097/j.pain.0000000000000838
10.1016/j.bja.2019.07.028
10.1093/pm/pnx019
10.1097/ALN.0000000000003428
10.1016/S0304-3959(98)00038-4
10.1111/anae.14769
10.1097/AJP.0b013e31819655ca
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References 2017; 42
2013; 26
2017; 2
2017; 3
2018; 129
2016; 32
1988; 33
2020; 14
2012; 18
2017; 152
2011; 152
2019; 160
2018; 43
2017; 158
2019; 123
2001; 87
2018; 6
2014; 4
2019; 63
1991; 44
2002; 300
2014; 15
2020; 133
2018; 31
2006; 367
2001; 413
2009; 25
2007; 245
2015; 6
2014; 90
2019; 74
2004; 48
2018; 22
2007; 55
2015; 8
2015; 7
1996; 12
2014; 113
2016; 11
2018; 19
2018; 18
2014; 348
2009; 32
2016; 2
2017; 17
2018; 159
2009; 9
2020; 24
2017; 18
2020; 21
2013
1998; 76
2018; 97
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Chaparro LE (e_1_2_9_43_1) 2013
Brummett CM (e_1_2_9_23_1) 2017; 152
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Liu FF (e_1_2_9_32_1) 2015; 8
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References_xml – volume: 6
  start-page: CD009642
  year: 2015
  article-title: Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery
  publication-title: Cochrane Database of Systematic Reviews
– volume: 2
  start-page: CD009121
  year: 2016
  article-title: Paravertebral block versus thoracic epidural for patients undergoing thoracotomy
  publication-title: Cochrane Database of Systematic Reviews
– volume: 18
  start-page: 45
  year: 2012
  end-page: 51
  article-title: Effect of the perioperative infusion of dexmedetomidine on chronic pain after breast surgery
  publication-title: Indian Journal of Palliative Care
– volume: 7
  start-page: 42
  year: 2015
  end-page: 54
  article-title: Intra‐ and postoperative intravenous ketamine does not prevent chronic pain: a systematic review and meta‐analysis
  publication-title: Scandinavian Journal of Pain
– volume: 160
  start-page: 88
  year: 2019
  end-page: 94
  article-title: The IASP classification of chronic pain for ICD‐11: functioning properties of chronic pain
  publication-title: Pain
– volume: 97
  year: 2018
  article-title: The effects of preoperative single‐dose thoracic paravertebral block on acute and chronic pain after thoracotomy: a randomized, controlled, double‐blind trial
  publication-title: Medicine
– volume: 15
  start-page: 241
  year: 2014
  end-page: 9
  article-title: The ACTTION‐American Pain Society Pain Taxonomy (AAPT): an evidence‐based and multidimensional approach to classifying chronic pain conditions
  publication-title: Journal of Pain
– volume: 25
  start-page: 263
  year: 2009
  end-page: 8
  article-title: A prospective study of risk factors for pain persisting 4 months after hysterectomy
  publication-title: Clinical Journal of Pain
– volume: 24
  start-page: 21
  year: 2020
  article-title: Dexmedetomidine in enhanced recovery after surgery (ERAS) protocols for postoperative pain
  publication-title: Current Pain and Headache Reports
– volume: 22
  start-page: 1
  year: 2018
  end-page: 6
  article-title: Chronification of pain: mechanisms, current understanding, and clinical implications
  publication-title: Current Pain and Headache Reports
– volume: 152
  start-page: S2
  year: 2011
  end-page: S15
  article-title: Central sensitization: implications for the diagnosis and treatment of pain
  publication-title: Pain
– start-page: CD008307
  year: 2013
  article-title: Pharmacotherapy for the prevention of chronic pain after surgery in adults
  publication-title: Cochrane Database of Systematic Reviews
– volume: 74
  start-page: 1277
  year: 2019
  end-page: 81
  article-title: A randomised controlled trial of the pectoral nerves‐2 (PECS‐2) block for radical mastectomy
  publication-title: Anaesthesia
– volume: 3
  start-page: 17002
  year: 2017
  article-title: Neuropathic pain
  publication-title: Nature Reviews Disease Primers
– volume: 2
  start-page: e627
  year: 2017
  article-title: Risk stratification for the development of chronic postsurgical pain
  publication-title: Pain Reports
– volume: 4
  start-page: 445
  year: 2014
  end-page: 59
  article-title: Predicting, preventing and managing persistent pain after breast cancer surgery: the importance of psychosocial factors
  publication-title: Pain Management
– volume: 19
  start-page: 2536
  year: 2018
  end-page: 45
  article-title: Postoperative pain trajectories and pain chronification – an empirical typology of pain patients
  publication-title: Pain Medicine
– volume: 12
  start-page: 50
  year: 1996
  end-page: 5
  article-title: Acute pain after thoracic surgery predicts long‐term post‐thoracotomy pain
  publication-title: Clinical Journal of Pain
– volume: 113
  start-page: 1
  year: 2014
  end-page: 4
  article-title: Defining persistent post‐surgical pain: is an update required?
  publication-title: British Journal of Anaesthesia
– volume: 32
  start-page: 1
  year: 2009
  article-title: Neuropathic pain: a maladaptive response of the nervous system to damage
  publication-title: Annual Review of Neuroscience
– volume: 123
  start-page: e293
  year: 2019
  end-page: e302
  article-title: Benefit of regional anaesthesia on postoperative pain following mastectomy: the influence of catastrophising
  publication-title: British Journal of Anaesthesia
– volume: 129
  start-page: 590
  year: 2018
  end-page: 607
  article-title: Persistent postsurgical pain: pathophysiology and preventative pharmacologic considerations
  publication-title: Anesthesiology
– volume: 43
  start-page: 521
  year: 2018
  end-page: 46
  article-title: Consensus guidelines on the use of intravenous ketamine infusions for chronic pain from the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists
  publication-title: Regional Anesthesia and Pain Medicine
– volume: 6
  start-page: CD007105
  year: 2018
  article-title: Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent postoperative pain in adults and children
  publication-title: Cochrane Database of Systematic Reviews
– volume: 9
  start-page: 723
  year: 2009
  end-page: 44
  article-title: Transition from acute to chronic postsurgical pain: risk factors and protective factors
  publication-title: Expert Review of Neurotherapeutics
– volume: 11
  year: 2016
  article-title: Memantine before mastectomy prevents post‐surgery pain: a randomized, blinded clinical trial in surgical patients
  publication-title: PLoS One
– volume: 300
  start-page: 282
  year: 2002
  end-page: 90
  article-title: alpha(2C)‐Adrenergic receptors mediate spinal analgesia and adrenergic‐opioid synergy
  publication-title: Journal of Pharmacology and Experimental Therapeutics
– volume: 33
  start-page: 289
  year: 1988
  end-page: 90
  article-title: The prevention of postoperative pain
  publication-title: Pain
– volume: 21
  start-page: 294
  year: 2020
  end-page: 305
  article-title: AAAPT diagnostic criteria for acute pain following breast surgery
  publication-title: Journal of Pain
– volume: 90
  start-page: 222
  year: 2014
  end-page: 7
  article-title: Chronic pain after surgery: pathophysiology, risk factors and prevention
  publication-title: Postgraduate Medical Journal
– volume: 8
  start-page: 5438
  year: 2015
  end-page: 45
  article-title: Postoperative continuous wound infusion of ropivacaine has comparable analgesic effects and fewer complications as compared to traditional patient‐controlled analgesia with sufentanil in patients undergoing non‐cardiac thoracotomy
  publication-title: International Journal of Clinical and Experimental Medicine
– volume: 245
  start-page: 487
  year: 2007
  end-page: 94
  article-title: Somatic and psychologic predictors of long‐term unfavorable outcome after surgical intervention
  publication-title: Annals of Surgery
– volume: 74
  start-page: 1558
  year: 2019
  end-page: 62
  article-title: A randomised controlled trial of pectoral nerve‐2 (PECS 2) block vs. serratus plane block for chronic pain after mastectomy
  publication-title: Anaesthesia
– volume: 159
  start-page: 1696
  year: 2018
  end-page: 704
  article-title: Perioperative lidocaine infusions for the prevention of chronic postsurgical pain: a systematic review and meta‐analysis of efficacy and safety
  publication-title: Pain
– volume: 367
  start-page: 1618
  year: 2006
  end-page: 25
  article-title: Persistent postsurgical pain: risk factors and prevention
  publication-title: Lancet
– volume: 42
  start-page: 184
  year: 2017
  end-page: 96
  article-title: Investigating the efficacy of dexmedetomidine as an adjuvant to local anesthesia in brachial plexus block: a systematic review and meta‐analysis of 18 randomized controlled trials
  publication-title: Regional Anesthesia and Pain Medicine
– volume: 18
  start-page: 443
  year: 2018
  end-page: 51
  article-title: Randomized controlled trial on the influence of intraoperative remifentanil versus fentanyl on acute and chronic pain after cardiac surgery
  publication-title: Pain Practice
– volume: 32
  start-page: 726
  year: 2016
  end-page: 35
  article-title: Is intraoperative remifentanil associated with acute or chronic postoperative pain after prolonged surgery? An update of the literature
  publication-title: Clinical Journal of Pain
– volume: 18
  start-page: 947
  year: 2017
  end-page: 58
  article-title: The ACTTION‐APS‐AAPM Pain Taxonomy (AAAPT) multidimensional approach to classifying acute pain conditions
  publication-title: Pain Medicine
– volume: 152
  year: 2017
  article-title: New persistent opioid use after minor and major surgical procedures in US adults
  publication-title: Journal of the American Medical Association: Surgery
– volume: 31
  start-page: 155
  year: 2018
  end-page: 73
  article-title: Chronic postsurgical pain: current evidence for prevention and management
  publication-title: Korean Journal of Pain
– volume: 48
  start-page: 111
  year: 2004
  end-page: 6
  article-title: Chronic pain following Caesarean section
  publication-title: Acta Anaesthesiologica Scandinavica
– volume: 348
  start-page: g1251
  year: 2014
  article-title: Rates and risk factors for prolonged opioid use after major surgery: population based cohort study
  publication-title: British Medical Journal
– volume: 26
  start-page: 621
  year: 2013
  end-page: 5
  article-title: Mechanisms of regional anaesthesia protection against hyperalgesia and pain chronicization
  publication-title: Current Opinion in Anesthesiology
– volume: 17
  start-page: 336
  year: 2017
  end-page: 43
  article-title: Effect of perioperative intravenous lidocaine infusion on acute and chronic pain after breast surgery: a meta‐analysis of Randomized Controlled Trials
  publication-title: Pain Practice
– volume: 160
  start-page: 45
  year: 2019
  end-page: 52
  article-title: The IASP classification of chronic pain for ICD‐11: chronic postsurgical or posttraumatic pain
  publication-title: Pain
– volume: 76
  start-page: 167
  year: 1998
  end-page: 71
  article-title: Cut and thrust: antecedent surgery and trauma among patients attending a chronic pain clinic
  publication-title: Pain
– volume: 413
  start-page: 203
  year: 2001
  end-page: 10
  article-title: Molecular mechanisms of nociception
  publication-title: Nature
– volume: 44
  start-page: 293
  year: 1991
  end-page: 9
  article-title: The induction and maintenance of central sensitization is dependent on N‐methyl‐d‐aspartic acid receptor activation; implications for the treatment of post‐injury pain hypersensitivity states
  publication-title: Pain
– volume: 55
  start-page: 353
  year: 2007
  end-page: 64
  article-title: Nociceptors‐noxious stimulus detectors
  publication-title: Neuron
– volume: 87
  start-page: 88
  year: 2001
  end-page: 98
  article-title: Chronic pain after surgery
  publication-title: British Journal of Anaesthesia
– volume: 63
  start-page: 63
  year: 2019
  end-page: 70
  article-title: The effect of transversus abdominis plane block on acute and chronic pain after inguinal hernia repair. A randomized controlled trial
  publication-title: International Journal of Surgery
– volume: 133
  start-page: 265
  year: 2020
  end-page: 79
  article-title: Perioperative use of gabapentinoids for the management of postoperative acute pain: a systematic review and meta‐analysis
  publication-title: Anesthesiology
– volume: 123
  start-page: 853
  year: 2019
  end-page: 64
  article-title: Dopaminergic neurotransmission and genetic variation in chronification of post‐surgical pain
  publication-title: British Journal of Anaesthesia
– volume: 123
  start-page: 335
  year: 2019
  end-page: 49
  article-title: Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review
  publication-title: British Journal of Anaesthesia
– volume: 158
  start-page: 775
  year: 2017
  end-page: 83
  article-title: Perioperative pregabalin administration does not prevent chronic postoperative pain: systematic review with a meta‐analysis of randomized trials
  publication-title: Pain
– volume: 14
  start-page: 793
  year: 2020
  article-title: Paravertebral block versus preemptive ketamine effect on pain intensity after posterolateral thoracotomies: a randomized controlled trial
  publication-title: Journal of Clinical Medicine
– ident: e_1_2_9_36_1
  doi: 10.1093/pm/pny099
– ident: e_1_2_9_54_1
  doi: 10.1124/jpet.300.1.282
– volume: 152
  start-page: e170504
  year: 2017
  ident: e_1_2_9_23_1
  article-title: New persistent opioid use after minor and major surgical procedures in US adults
  publication-title: Journal of the American Medical Association: Surgery
– volume: 2
  start-page: CD009121
  year: 2016
  ident: e_1_2_9_33_1
  article-title: Paravertebral block versus thoracic epidural for patients undergoing thoracotomy
  publication-title: Cochrane Database of Systematic Reviews
– ident: e_1_2_9_46_1
  doi: 10.1371/journal.pone.0152741
– ident: e_1_2_9_14_1
  doi: 10.1016/j.neuron.2007.07.016
– ident: e_1_2_9_16_1
  doi: 10.3344/kjp.2018.31.3.155
– ident: e_1_2_9_9_1
  doi: 10.1016/j.jpain.2019.08.008
– ident: e_1_2_9_48_1
  doi: 10.1097/j.pain.0000000000001273
– ident: e_1_2_9_34_1
  doi: 10.3390/jcm9030793
– ident: e_1_2_9_51_1
  doi: 10.1136/bmj.g1251
– ident: e_1_2_9_20_1
  doi: 10.1097/00002508-199603000-00009
– ident: e_1_2_9_47_1
  doi: 10.1136/postgradmedj-2013-132215
– ident: e_1_2_9_55_1
  doi: 10.4103/0973-1075.97354
– ident: e_1_2_9_3_1
  doi: 10.1097/j.pain.0000000000001413
– volume: 6
  start-page: CD007105
  year: 2018
  ident: e_1_2_9_6_1
  article-title: Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent postoperative pain in adults and children
  publication-title: Cochrane Database of Systematic Reviews
– ident: e_1_2_9_17_1
  doi: 10.1097/01.sla.0000245495.79781.65
– ident: e_1_2_9_44_1
  doi: 10.1016/j.sjpain.2014.12.005
– ident: e_1_2_9_40_1
  doi: 10.1016/0304-3959(88)90286-2
– ident: e_1_2_9_26_1
  doi: 10.1111/papr.12615
– ident: e_1_2_9_7_1
  doi: 10.1097/PR9.0000000000000627
– ident: e_1_2_9_57_1
  doi: 10.1097/AAP.0000000000000564
– ident: e_1_2_9_15_1
  doi: 10.1586/ern.09.20
– ident: e_1_2_9_49_1
  doi: 10.1111/papr.12442
– volume: 6
  start-page: CD009642
  year: 2015
  ident: e_1_2_9_50_1
  article-title: Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery
  publication-title: Cochrane Database of Systematic Reviews
– ident: e_1_2_9_28_1
  doi: 10.1097/MD.0000000000011181
– ident: e_1_2_9_56_1
  doi: 10.1007/s11916-020-00853-z
– ident: e_1_2_9_41_1
  doi: 10.1016/0304-3959(91)90100-C
– ident: e_1_2_9_29_1
  doi: 10.1016/j.ijsu.2019.02.007
– ident: e_1_2_9_22_1
  doi: 10.1016/j.bja.2019.06.014
– ident: e_1_2_9_19_1
  doi: 10.2217/pmt.14.33
– ident: e_1_2_9_27_1
  doi: 10.1111/anae.14856
– ident: e_1_2_9_38_1
  doi: 10.1093/bja/87.1.88
– ident: e_1_2_9_5_1
  doi: 10.1016/S0140-6736(06)68700-X
– ident: e_1_2_9_11_1
  doi: 10.1097/j.pain.0000000000001433
– ident: e_1_2_9_35_1
  doi: 10.1111/j.1399-6576.2004.00271.x
– ident: e_1_2_9_25_1
  doi: 10.1097/AJP.0000000000000317
– ident: e_1_2_9_58_1
  doi: 10.1007/s11916-018-0666-8
– ident: e_1_2_9_39_1
  doi: 10.1038/nrdp.2017.2
– start-page: CD008307
  year: 2013
  ident: e_1_2_9_43_1
  article-title: Pharmacotherapy for the prevention of chronic pain after surgery in adults
  publication-title: Cochrane Database of Systematic Reviews
– ident: e_1_2_9_2_1
  doi: 10.1093/bja/aeu012
– ident: e_1_2_9_21_1
  doi: 10.1097/01.aco.0000432511.08070.de
– ident: e_1_2_9_30_1
  doi: 10.1016/j.pain.2010.09.030
– ident: e_1_2_9_13_1
  doi: 10.1146/annurev.neuro.051508.135531
– ident: e_1_2_9_12_1
  doi: 10.1038/35093019
– ident: e_1_2_9_24_1
  doi: 10.1016/j.bja.2019.01.041
– ident: e_1_2_9_8_1
  doi: 10.1016/j.jpain.2014.01.004
– ident: e_1_2_9_45_1
  doi: 10.1097/ALN.0000000000002238
– volume: 8
  start-page: 5438
  year: 2015
  ident: e_1_2_9_32_1
  article-title: Postoperative continuous wound infusion of ropivacaine has comparable analgesic effects and fewer complications as compared to traditional patient‐controlled analgesia with sufentanil in patients undergoing non‐cardiac thoracotomy
  publication-title: International Journal of Clinical and Experimental Medicine
– ident: e_1_2_9_52_1
  doi: 10.1097/j.pain.0000000000000838
– ident: e_1_2_9_18_1
  doi: 10.1016/j.bja.2019.07.028
– ident: e_1_2_9_10_1
  doi: 10.1093/pm/pnx019
– ident: e_1_2_9_53_1
  doi: 10.1097/ALN.0000000000003428
– ident: e_1_2_9_4_1
  doi: 10.1016/S0304-3959(98)00038-4
– ident: e_1_2_9_31_1
  doi: 10.1111/anae.14769
– ident: e_1_2_9_37_1
  doi: 10.1097/AJP.0b013e31819655ca
– volume: 43
  start-page: 521
  year: 2018
  ident: e_1_2_9_42_1
  article-title: Consensus guidelines on the use of intravenous ketamine infusions for chronic pain from the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists
  publication-title: Regional Anesthesia and Pain Medicine
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Snippet Summary Effective prevention of chronic postoperative pain is an important clinical goal, informed by a growing body of studies. Peri‐operative regional...
Effective prevention of chronic postoperative pain is an important clinical goal, informed by a growing body of studies. Peri‐operative regional anaesthesia...
Effective prevention of chronic postoperative pain is an important clinical goal, informed by a growing body of studies. Peri-operative regional anaesthesia...
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StartPage 8
SubjectTerms Analgesia
Analgesia - methods
Analgesics
Anesthesia
Anesthesia, Conduction - methods
Central nervous system
Chronic Pain - prevention & control
chronic postoperative pain
Heterogeneity
Humans
multimodal analgesia
Pain
Pain Management - methods
Pain perception
Pain, Postoperative - prevention & control
Postoperative period
Prevention
regional anaesthesia
Regional anesthesia
Risk assessment
Risk Factors
Taxonomy
Title The role of regional anaesthesia and multimodal analgesia in the prevention of chronic postoperative pain: a narrative review
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fanae.15256
https://www.ncbi.nlm.nih.gov/pubmed/33426669
https://www.proquest.com/docview/2476499820
https://www.proquest.com/docview/2476846287
https://pubmed.ncbi.nlm.nih.gov/PMC8369227
Volume 76
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