Caution against examining the role of reverse causality in Mendelian Randomization

Recently, Mendelian Randomization (MR) has gained in popularity as a concept to assess the causal relationship between phenotypes in genetic association studies. An extension of standard MR methodology, the MR Steiger approach, has recently been developed to infer the causal direction between two ph...

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Bibliographic Details

Published in:	Genetic epidemiology Vol. 45; no. 5; pp. 445 - 454
Main Authors:	Lutz, Sharon M., Wu, Ann Chen, Hokanson, John E., Vansteelandt, Stijn, Lange, Christoph
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.07.2021
Subjects:	causal direction Causality Chronic obstructive pulmonary disease Lung diseases Mendelian Randomization Obstructive lung disease Phenotypes Pleiotropy Respiratory function reverse causality causal direction reverse causality Mendelian Randomization
ISSN:	0741-0395, 1098-2272, 1098-2272
Online Access:	Get full text
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