Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids

Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all aspects of a cell's life and death. T...

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Bibliographic Details
Published in:Biochemical journal Vol. 476; no. 1; p. 1
Main Authors: Dickson, Eamonn J, Hille, Bertil
Format: Journal Article
Language:English
Published: England 07.01.2019
Subjects:
Animals
Cell Membrane - metabolism
Humans
Membrane Proteins - metabolism
Phosphatidylinositols - metabolism
Signal Transduction
transmembrane proteins
PTEN
phosphatidylinositol
lipid transfer
phosphoinositide 3-kinase
ISSN:1470-8728, 1470-8728
Online Access:Get more information
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Summary:Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all aspects of a cell's life and death. They do so by recruiting cytoplasmic proteins/effectors or by interacting with cytoplasmic domains of membrane proteins at the membrane-cytoplasm interface to organize and mold organelle identity. The present study summarizes aspects of our current understanding concerning the metabolism, manipulation, measurement, and intimate roles these lipids play in regulating membrane homeostasis and vital cell signaling reactions in health and disease.
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ISSN:1470-8728
1470-8728
DOI:10.1042/BCJ20180022