Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids

Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all aspects of a cell's life and death. T...

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Veröffentlicht in:Biochemical journal Jg. 476; H. 1; S. 1
Hauptverfasser: Dickson, Eamonn J, Hille, Bertil
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 07.01.2019
Schlagworte:
Animals
Cell Membrane - metabolism
Humans
Membrane Proteins - metabolism
Phosphatidylinositols - metabolism
Signal Transduction
transmembrane proteins
PTEN
phosphatidylinositol
lipid transfer
phosphoinositide 3-kinase
ISSN:1470-8728, 1470-8728
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Zusammenfassung:Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all aspects of a cell's life and death. They do so by recruiting cytoplasmic proteins/effectors or by interacting with cytoplasmic domains of membrane proteins at the membrane-cytoplasm interface to organize and mold organelle identity. The present study summarizes aspects of our current understanding concerning the metabolism, manipulation, measurement, and intimate roles these lipids play in regulating membrane homeostasis and vital cell signaling reactions in health and disease.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1470-8728
1470-8728
DOI:10.1042/BCJ20180022