Swept-Source OCT Angiography of the Retinal Vasculature Using Intensity Differentiation-based Optical Microangiography Algorithms

To demonstrate the feasibility of using a 1,050-nm swept-source optical coherence tomography (SS-OCT) system to achieve noninvasive retinal vasculature imaging in human eyes. Volumetric data sets were acquired using a 1-µm SS-OCT prototype that operated at a 100-kHz A-line rate. A scanning protocol...

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Veröffentlicht in:Ophthalmic surgery, lasers & imaging Jg. 45; H. 5; S. 382 - 389
Hauptverfasser: Huang, Yanping, Zhang, Qinqin, Thorell, Mariana R., An, Lin, Durbin, Mary K., Laron, Michal, Sharma, Utkarsh, Gregori, Giovanni, Rosenfeld, Philip J., Wang, Ruikang K.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States SLACK INCORPORATED 01.09.2014
Schlagworte:
Adult
Algorithms
Cell Count
Eyes & eyesight
Female
Fluorescein Angiography - methods
Fundus Oculi
Healthy Volunteers
Humans
Imaging, Three-Dimensional
Male
Medical imaging
Middle Aged
Reproducibility of Results
Retina
Retinal Vessels - cytology
Tomography, Optical Coherence - methods
Veins & arteries
ISSN:2325-8160, 2325-8179, 2325-8179
Online-Zugang:Volltext
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Zusammenfassung:To demonstrate the feasibility of using a 1,050-nm swept-source optical coherence tomography (SS-OCT) system to achieve noninvasive retinal vasculature imaging in human eyes. Volumetric data sets were acquired using a 1-µm SS-OCT prototype that operated at a 100-kHz A-line rate. A scanning protocol designed to allow for motion contrast processing, referred to as OCT angiography or optical microangiography (OMAG), was used to scan an approximately 3 × 3–mm area in the central macular region of the retina within approximately 4.5 seconds. An intensity differentiation-based OMAG algorithm was used to extract three-dimensional retinal functional microvasculature information. Intensity signal differentiation generated capillary-level resolution en face OMAG images of the retina. The parafoveal capillaries were clearly visible, thereby allowing visualization of the foveal avascular zone in healthy subjects. The capability of OMAG to produce retinal vascular images was demonstrated using the 1-µm SS-OCT prototype. This technique has potential clinical value for studying retinal vasculature abnormalities.
Bibliographie:ObjectType-Article-1
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ISSN:2325-8160
2325-8179
2325-8179
DOI:10.3928/23258160-20140909-08