A flexible state-space approach for the modeling of metabolic networks I: Development of mathematical methods

We introduce a novel, flexible, optimization-based mathematical framework for the modeling of arbitrarily complex metabolic networks: topological metabolic analysis (TMA). The framework is adapted from state-space approaches used by Manousiouthakis and co-workers for the representation of complex he...

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Bibliographic Details
Published in:	Metabolic engineering Vol. 13; no. 2; pp. 125 - 137
Main Authors:	Baughman, Adam C., Sharfstein, Susan T., Martin, Lealon L.
Format:	Journal Article
Language:	English
Published:	Belgium Elsevier Inc 01.03.2011
Subjects:	Algorithms Bacteria - metabolism bioengineering Carbon Isotopes - metabolism Global optimization least squares Metabolic modeling Metabolic Networks and Pathways metabolites Models, Biological Monte Carlo Method Network topology Numerical Analysis, Computer-Assisted secretion stable isotopes topology Global optimization Metabolic modeling Network topology
ISSN:	1096-7176, 1096-7184, 1096-7184
Online Access:	Get full text
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