A Novel Aeromonas popoffii Phage AerP_220 Proposed to Be a Member of a New Tolavirus Genus in the Autographiviridae Family

Aeromonas popoffii is one of the environmental Aeromonas species. A number of factors of virulence have been described for this species and it has been reported as a causative agent of urinary tract infection. The first A. popoffii bacteriophage AerP_220 along with its host strain A. popoffii CEMTC...

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Veröffentlicht in:Viruses Jg. 14; H. 12; S. 2733
Hauptverfasser: Morozova, Vera, Kozlova, Yuliya, Jdeed, Ghadeer, Tikunov, Artem, Ushakova, Tatyana, Bardasheva, Alevtina, Zhirakovskaia, Elena, Poletaeva, Yuliya, Ryabchikova, Elena, Tikunova, Nina V.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 07.12.2022
Schlagworte:
Aeromonas
Aeromonas - genetics
Aeromonas popoffii
Antibiotic resistance
Antibiotics
Autographiviridae
Bacteria
bacteriophage
Bacteriophages
comparative genomics
etiological agents
Experiments
genome
Genome, Viral
Genomes
Genomic analysis
Genomics
Host range
Infections
Morphology
morphs
Pantoea
Phages
Phylogeny
Podoviridae
Polyethylene glycol
proteomic analysis
Proteomics
river water
Seafood
sequence analysis
tail fiber
toxins
Urinary tract
urinary tract diseases
Virulence
United Kingdom > UK
United States > US
Germany
Russia
Aeromonas popoffii
Tolavirus
tail fiber
bacteriophage
comparative genomics
Autographiviridae
proteomic analysis
ISSN:1999-4915, 1999-4915
Online-Zugang:Volltext
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Zusammenfassung:Aeromonas popoffii is one of the environmental Aeromonas species. A number of factors of virulence have been described for this species and it has been reported as a causative agent of urinary tract infection. The first A. popoffii bacteriophage AerP_220 along with its host strain A. popoffii CEMTC 4062 were isolated from river water. The phage has a podovirus morphotype, shows a narrow host range and is lytic against the host strain. The AerP_220 genome comprises 45,207 bp and does not contain genes responsible for antibiotic resistance and toxin production. Fifty-nine co-directional putative ORFs were found in the AerP_220 genome. Thirty-three ORFs encoded proteins with predicted functions; the products of 26 ORFs were hypothetical proteins. AerP_220 genome analysis revealed that this phage can be considered a novel species within the Autographiviridae family. Comparative genomic and proteomic analysis revealed that AerP_220 along with the Aeromonas phage vB_AspA_Tola (OM913599) are members of a new putative Tolavirus genus in the family Autographiviridae. The Gajwadongvirus and proposed Tolavirus genera along with Pantoea phage Nufs112 and phage Reminis could form a new Tolavirinae subfamily within the Autographiviridae family.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1999-4915
1999-4915
DOI:10.3390/v14122733