ctDNA monitoring using patient-specific sequencing and integration of variant reads

Circulating tumor-derived DNA (ctDNA) can be used to monitor cancer dynamics noninvasively. Detection of ctDNA can be challenging in patients with low-volume or residual disease, where plasma contains very few tumor-derived DNA fragments. We show that sensitivity for ctDNA detection in plasma can be...

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Bibliographic Details

Published in:	Science translational medicine Vol. 12; no. 548
Main Authors:	Wan, Jonathan C M, Heider, Katrin, Gale, Davina, Murphy, Suzanne, Fisher, Eyal, Mouliere, Florent, Ruiz-Valdepenas, Andrea, Santonja, Angela, Morris, James, Chandrananda, Dineika, Marshall, Andrea, Gill, Andrew B, Chan, Pui Ying, Barker, Emily, Young, Gemma, Cooper, Wendy N, Hudecova, Irena, Marass, Francesco, Mair, Richard, Brindle, Kevin M, Stewart, Grant D, Abraham, Jean E, Caldas, Carlos, Rassl, Doris M, Rintoul, Robert C, Alifrangis, Constantine, Middleton, Mark R, Gallagher, Ferdia A, Parkinson, Christine, Durrani, Amer, McDermott, Ultan, Smith, Christopher G, Massie, Charles, Corrie, Pippa G, Rosenfeld, Nitzan
Format:	Journal Article
Language:	English
Published:	United States 17.06.2020
Subjects:	Biomarkers, Tumor Circulating Tumor DNA - genetics DNA, Neoplasm - genetics High-Throughput Nucleotide Sequencing Humans Liquid Biopsy Mutation - genetics
ISSN:	1946-6242, 1946-6242
Online Access:	Get more information
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