Bacteria autoaggregation: how and why bacteria stick together

Autoaggregation, adherence between identical bacterial cells, is important for colonization, kin and kind recognition, and survival of bacteria. It is directly mediated by specific interactions between proteins or organelles on the surfaces of interacting cells or indirectly by the presence of secre...

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Bibliographic Details
Published in:Biochemical Society transactions Vol. 49; no. 3; p. 1147
Main Authors: Nwoko, El-Shama Q A, Okeke, Iruka N
Format: Journal Article
Language:English
Published: England 30.06.2021
Subjects:
Bacteria - genetics
Bacteria - growth & development
Bacteria - metabolism
Bacterial Adhesion - genetics
Bacterial Adhesion - physiology
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacterial Secretion Systems - genetics
Bacterial Secretion Systems - metabolism
Biofilms - growth & development
Gene Expression Regulation, Bacterial
Membrane Proteins - genetics
Membrane Proteins - metabolism
Microbial Viability - genetics
Phase Variation - genetics
Phase Variation - physiology
Protein Binding
self-associating
autoaggregation
adherence
biofilm
ISSN:1470-8752, 1470-8752
Online Access:Get more information
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Summary:Autoaggregation, adherence between identical bacterial cells, is important for colonization, kin and kind recognition, and survival of bacteria. It is directly mediated by specific interactions between proteins or organelles on the surfaces of interacting cells or indirectly by the presence of secreted macromolecules such as eDNA and exopolysaccharides. Some autoaggregation effectors are self-associating and present interesting paradigms for protein interaction. Autoaggregation can be beneficial or deleterious at specific times and niches. It is, therefore, typically regulated through transcriptional or post-transcriptional mechanisms or epigenetically by phase variation. Autoaggregation can contribute to bacterial adherence, biofilm formation or other higher-level functions. However, autoaggregation is only required for these phenotypes in some bacteria. Thus, autoaggregation should be detected, studied and measured independently using both qualitative and quantitative in vitro and ex vivo methods. If better understood, autoaggregation holds the potential for the discovery of new therapeutic targets that could be cost-effectively exploited.
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ISSN:1470-8752
1470-8752
DOI:10.1042/BST20200718