Bacteria autoaggregation: how and why bacteria stick together

Autoaggregation, adherence between identical bacterial cells, is important for colonization, kin and kind recognition, and survival of bacteria. It is directly mediated by specific interactions between proteins or organelles on the surfaces of interacting cells or indirectly by the presence of secre...

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Podrobná bibliografia
Vydané v:	Biochemical Society transactions Ročník 49; číslo 3; s. 1147
Hlavní autori:	Nwoko, El-Shama Q A, Okeke, Iruka N
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 30.06.2021
Predmet:	Bacteria - genetics Bacteria - growth & development Bacteria - metabolism Bacterial Adhesion - genetics Bacterial Adhesion - physiology Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Secretion Systems - genetics Bacterial Secretion Systems - metabolism Biofilms - growth & development Gene Expression Regulation, Bacterial Membrane Proteins - genetics Membrane Proteins - metabolism Microbial Viability - genetics Phase Variation - genetics Phase Variation - physiology Protein Binding self-associating autoaggregation adherence biofilm
ISSN:	1470-8752, 1470-8752
On-line prístup:	Zistit podrobnosti o prístupe
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Popis
Shrnutí:	Autoaggregation, adherence between identical bacterial cells, is important for colonization, kin and kind recognition, and survival of bacteria. It is directly mediated by specific interactions between proteins or organelles on the surfaces of interacting cells or indirectly by the presence of secreted macromolecules such as eDNA and exopolysaccharides. Some autoaggregation effectors are self-associating and present interesting paradigms for protein interaction. Autoaggregation can be beneficial or deleterious at specific times and niches. It is, therefore, typically regulated through transcriptional or post-transcriptional mechanisms or epigenetically by phase variation. Autoaggregation can contribute to bacterial adherence, biofilm formation or other higher-level functions. However, autoaggregation is only required for these phenotypes in some bacteria. Thus, autoaggregation should be detected, studied and measured independently using both qualitative and quantitative in vitro and ex vivo methods. If better understood, autoaggregation holds the potential for the discovery of new therapeutic targets that could be cost-effectively exploited.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1470-8752 1470-8752
DOI:	10.1042/BST20200718