Tumor-mediated immunosuppression and cytokine spreading affects the relation between EMT and PD-L1 status

Epithelial-mesenchymal transition (EMT) and immune resistance mediated by Programmed Death-Ligand 1 (PD-L1) upregulation are established drivers of tumor progression. Their bi-directional crosstalk has been proposed to facilitate tumor immunoevasion, yet the impact of immunosuppression and spatial h...

Full description

Bibliographic Details

Published in:	Frontiers in immunology Vol. 14; p. 1219669
Main Authors:	Lems, Carlijn M., Burger, Gerhard A., Beltman, Joost B.
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 10.08.2023
Subjects:	cellular Potts model epithelial-mesenchymal transition (EMT) immunoevasion Immunology ordinary differential equations PD-L1
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!