Tumor-mediated immunosuppression and cytokine spreading affects the relation between EMT and PD-L1 status

Epithelial-mesenchymal transition (EMT) and immune resistance mediated by Programmed Death-Ligand 1 (PD-L1) upregulation are established drivers of tumor progression. Their bi-directional crosstalk has been proposed to facilitate tumor immunoevasion, yet the impact of immunosuppression and spatial h...

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Veröffentlicht in:	Frontiers in immunology Jg. 14; S. 1219669
Hauptverfasser:	Lems, Carlijn M., Burger, Gerhard A., Beltman, Joost B.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Frontiers Media S.A 10.08.2023
Schlagworte:	cellular Potts model epithelial-mesenchymal transition (EMT) immunoevasion Immunology ordinary differential equations PD-L1
ISSN:	1664-3224, 1664-3224
Online-Zugang:	Volltext
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