Software updates of OCT segmentation algorithms influence longitudinal assessment of retinal atrophy

To investigate whether there is a systematic difference in peripapillary retinal nerve fiber layer (pRNFL) thickness measurements between subsequent updates of pRNFL segmentation software provided by Heidelberg Spectralis optical coherence tomography (OCT). In total, 838 pRNFL scans from 213 multipl...

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Vydané v:Journal of the neurological sciences Ročník 387; s. 16 - 20
Hlavní autori: Coric, Danko, Petzold, Axel, Uitdehaag, Bernard M.J., Balk, Lisanne J.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Netherlands Elsevier B.V 15.04.2018
Predmet:
Bland-Altman analysis
Multiple sclerosis
Neuro-ophthalmology
Optical coherence tomography
Retinal layer segmentation
Retinal nerve fiber layer
Retinal layer segmentation
OCT
Multiple sclerosis
pRNFL
Retinal nerve fiber layer
Optical coherence tomography
NS
MS
N
T
TI
Bland-Altman analysis
HC
NI
Neuro-ophthalmology
TS
ISSN:0022-510X, 1878-5883, 1878-5883
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Popis
Shrnutí:To investigate whether there is a systematic difference in peripapillary retinal nerve fiber layer (pRNFL) thickness measurements between subsequent updates of pRNFL segmentation software provided by Heidelberg Spectralis optical coherence tomography (OCT). In total, 838 pRNFL scans from 213 multiple sclerosis (MS) patients and 61 healthy controls were analyzed. All scans were performed on the same OCT device followed by automated segmentation (HRA 5.6.4.0) and data extraction. Subsequently, all scans were re-segmented with an updated software version (HRA 6.0.7.0). To assess level of agreement between the two algorithms, Bland-Altman Plots were constructed. Paired samples t-test and linear regression analyses were used to investigate for differences in mean thickness and proportional bias respectively. Overall, the updated version showed an overestimation of 0.16μm [95%CI 0.097–0.23, p<0.001] for the global pRNFL thickness compared to the earlier version. The largest differences were found for the nasal inferior (mean ∆ 0.29μm, p<0.001) and temporal inferior (mean ∆ 0.43μm, p<0.001) sectors. Inspection of the Bland-Altman Plot revealed that the difference between the two versions could be up to 6μm for the global mean. There was no proportional bias for the global mean (β=0.003, p=0.245) nor for any of the separate sectors. The data show a significant difference in pRNFL thickness measurements between two subsequent versions of the same segmentation software. Although the mean difference was relatively small, the differences within the individual subject could be considerably higher than the known atrophy rate of 1μm/year in MS. •The effect of updating a retinal nerve fiber layer segmentation algorithm is studied.•Using different versions for subsequent scans leads to biased thickness measurements.•The error can be greater than the expected atrophy rate in multiple sclerosis.•All subsequent scans should be segmented with the same software version.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-510X
1878-5883
1878-5883
DOI:10.1016/j.jns.2018.01.020