Interoceptive inference: From computational neuroscience to clinic

•Homeostatic interoceptive signal influence efferent autonomic outflow.•Predictive coding frameworks can elucidate interoceptive and autonomic symbiosis.•We describe interoceptive and autonomic symbiosis using interoceptive inference.•We summarise our empirical application of interoceptive inference...

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Published in:Neuroscience and biobehavioral reviews Vol. 90; pp. 174 - 183
Main Authors: Owens, Andrew P., Allen, Micah, Ondobaka, Sasha, Friston, Karl J.
Format: Journal Article
Language:English
Published: United States Elsevier Ltd 01.07.2018
Subjects:
Active inference
Autonomic nervous system
Awareness - physiology
Brain - physiology
Cognition - physiology
Emotions - physiology
Free-energy principle
Homeostasis
Humans
Interoception
Interoception - physiology
Interoceptive inference
Neurosciences
Predictive coding
Interoception
Autonomic nervous system
Active inference
Free-energy principle
Homeostasis
Predictive coding
Interoceptive inference
ISSN:0149-7634, 1873-7528, 1873-7528
Online Access:Get full text
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Summary:•Homeostatic interoceptive signal influence efferent autonomic outflow.•Predictive coding frameworks can elucidate interoceptive and autonomic symbiosis.•We describe interoceptive and autonomic symbiosis using interoceptive inference.•We summarise our empirical application of interoceptive inference to dysautonomia.•We report preliminary findings linking altered interoception to psychopathology. The central and autonomic nervous systems can be defined by their anatomical, functional and neurochemical characteristics, but neither functions in isolation. For example, fundamental components of autonomically mediated homeostatic processes are afferent interoceptive signals reporting the internal state of the body and efferent signals acting on interoceptive feedback assimilated by the brain. Recent predictive coding (interoceptive inference) models formulate interoception in terms of embodied predictive processes that support emotion and selfhood. We propose interoception may serve as a way to investigate holistic nervous system function and dysfunction in disorders of brain, body and behaviour. We appeal to predictive coding and (active) interoceptive inference, to describe the homeostatic functions of the central and autonomic nervous systems. We do so by (i) reviewing the active inference formulation of interoceptive and autonomic function, (ii) survey clinical applications of this formulation and (iii) describe how it offers an integrative approach to human physiology; particularly, interactions between the central and peripheral nervous systems in health and disease.
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ISSN:0149-7634
1873-7528
1873-7528
DOI:10.1016/j.neubiorev.2018.04.017