Association between adult-onset hearing loss and dementia biomarkers: A systematic review
People with adult-onset hearing loss (AoHL) are at increased dementia risk. In this study, we explore potential aetiological mechanisms by synthesising the evidence on the association between AoHL and neuropathological, cerebrospinal fluid (CSF), blood and imaging biomarkers of dementia. We systemat...
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| Published in: | Ageing research reviews Vol. 104; p. 102647 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
01.02.2025
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| ISSN: | 1568-1637, 1872-9649, 1872-9649 |
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| Abstract | People with adult-onset hearing loss (AoHL) are at increased dementia risk. In this study, we explore potential aetiological mechanisms by synthesising the evidence on the association between AoHL and neuropathological, cerebrospinal fluid (CSF), blood and imaging biomarkers of dementia.
We systematically searched electronic databases from inception to 30 April 2024 for cross-sectional and longitudinal studies, including quantitative data on the association between AoHL and dementia biomarkers. Study quality was assessed with the Mixed Methods Appraisal Tool (MMAT).
Sixty-six studies reporting 63 cross-sectional and 10 longitudinal analyses were included. Twenty-one studies met all MMAT quality criteria. We report a narrative synthesis due to the heterogeneity of the included studies. In CSF-based or blood-based assays or imaging, five out of six cross-sectional analyses found that AoHL was associated with elevated in vivo tau levels, whilst four out of 17 reported a link with elevated in vivo β-amyloid measures. One longitudinal analysis identified an association between AoHL and a steeper increase of CSF tau, but not Aβ42, levels over time. Twenty-five out of 44 cross-sectional and six out of nine longitudinal analyses identified associations between AoHL and grey matter atrophy of the temporal regions, particularly the medial temporal lobe. Studies using other biomarkers had inconsistent findings.
AoHL was usually associated with more temporal regions grey matter atrophy both cross-sectionally and longitudinally, and elevated in vivo tau but not β-amyloid. Increasing atrophy and higher tau, leading to decreased cognitive reserve may be how hearing loss increases dementia risk.
•Adult-onset hearing loss is associated with elevated in vivo brain tau levels.•Adult-onset hearing loss is associated with atrophy of the medial temporal lobe.•Reports of associations with other dementia biomarkers are less consistent.•Tau and temporal atrophy may underlie the association between AoHL and dementia. |
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| AbstractList | People with adult-onset hearing loss (AoHL) are at increased dementia risk. In this study, we explore potential aetiological mechanisms by synthesising the evidence on the association between AoHL and neuropathological, cerebrospinal fluid (CSF), blood and imaging biomarkers of dementia.BACKGROUND AND OBJECTIVEPeople with adult-onset hearing loss (AoHL) are at increased dementia risk. In this study, we explore potential aetiological mechanisms by synthesising the evidence on the association between AoHL and neuropathological, cerebrospinal fluid (CSF), blood and imaging biomarkers of dementia.We systematically searched electronic databases from inception to 30 April 2024 for cross-sectional and longitudinal studies, including quantitative data on the association between AoHL and dementia biomarkers. Study quality was assessed with the Mixed Methods Appraisal Tool (MMAT).METHODSWe systematically searched electronic databases from inception to 30 April 2024 for cross-sectional and longitudinal studies, including quantitative data on the association between AoHL and dementia biomarkers. Study quality was assessed with the Mixed Methods Appraisal Tool (MMAT).Sixty-six studies reporting 63 cross-sectional and 10 longitudinal analyses were included. Twenty-one studies met all MMAT quality criteria. We report a narrative synthesis due to the heterogeneity of the included studies. In CSF-based or blood-based assays or imaging, five out of six cross-sectional analyses found that AoHL was associated with elevated in vivo tau levels, whilst four out of 17 reported a link with elevated in vivo β-amyloid measures. One longitudinal analysis identified an association between AoHL and a steeper increase of CSF tau, but not Aβ42, levels over time. Twenty-five out of 44 cross-sectional and six out of nine longitudinal analyses identified associations between AoHL and grey matter atrophy of the temporal regions, particularly the medial temporal lobe. Studies using other biomarkers had inconsistent findings.RESULTSSixty-six studies reporting 63 cross-sectional and 10 longitudinal analyses were included. Twenty-one studies met all MMAT quality criteria. We report a narrative synthesis due to the heterogeneity of the included studies. In CSF-based or blood-based assays or imaging, five out of six cross-sectional analyses found that AoHL was associated with elevated in vivo tau levels, whilst four out of 17 reported a link with elevated in vivo β-amyloid measures. One longitudinal analysis identified an association between AoHL and a steeper increase of CSF tau, but not Aβ42, levels over time. Twenty-five out of 44 cross-sectional and six out of nine longitudinal analyses identified associations between AoHL and grey matter atrophy of the temporal regions, particularly the medial temporal lobe. Studies using other biomarkers had inconsistent findings.AoHL was usually associated with more temporal regions grey matter atrophy both cross-sectionally and longitudinally, and elevated in vivo tau but not β-amyloid. Increasing atrophy and higher tau, leading to decreased cognitive reserve may be how hearing loss increases dementia risk.CONCLUSIONSAoHL was usually associated with more temporal regions grey matter atrophy both cross-sectionally and longitudinally, and elevated in vivo tau but not β-amyloid. Increasing atrophy and higher tau, leading to decreased cognitive reserve may be how hearing loss increases dementia risk. People with adult-onset hearing loss (AoHL) are at increased dementia risk. In this study, we explore potential aetiological mechanisms by synthesising the evidence on the association between AoHL and neuropathological, cerebrospinal fluid (CSF), blood and imaging biomarkers of dementia. We systematically searched electronic databases from inception to 30 April 2024 for cross-sectional and longitudinal studies, including quantitative data on the association between AoHL and dementia biomarkers. Study quality was assessed with the Mixed Methods Appraisal Tool (MMAT). Sixty-six studies reporting 63 cross-sectional and 10 longitudinal analyses were included. Twenty-one studies met all MMAT quality criteria. We report a narrative synthesis due to the heterogeneity of the included studies. In CSF-based or blood-based assays or imaging, five out of six cross-sectional analyses found that AoHL was associated with elevated in vivo tau levels, whilst four out of 17 reported a link with elevated in vivo β-amyloid measures. One longitudinal analysis identified an association between AoHL and a steeper increase of CSF tau, but not Aβ42, levels over time. Twenty-five out of 44 cross-sectional and six out of nine longitudinal analyses identified associations between AoHL and grey matter atrophy of the temporal regions, particularly the medial temporal lobe. Studies using other biomarkers had inconsistent findings. AoHL was usually associated with more temporal regions grey matter atrophy both cross-sectionally and longitudinally, and elevated in vivo tau but not β-amyloid. Increasing atrophy and higher tau, leading to decreased cognitive reserve may be how hearing loss increases dementia risk. •Adult-onset hearing loss is associated with elevated in vivo brain tau levels.•Adult-onset hearing loss is associated with atrophy of the medial temporal lobe.•Reports of associations with other dementia biomarkers are less consistent.•Tau and temporal atrophy may underlie the association between AoHL and dementia. People with adult-onset hearing loss (AoHL) are at increased dementia risk. In this study, we explore potential aetiological mechanisms by synthesising the evidence on the association between AoHL and neuropathological, cerebrospinal fluid (CSF), blood and imaging biomarkers of dementia. We systematically searched electronic databases from inception to 30 April 2024 for cross-sectional and longitudinal studies, including quantitative data on the association between AoHL and dementia biomarkers. Study quality was assessed with the Mixed Methods Appraisal Tool (MMAT). Sixty-six studies reporting 63 cross-sectional and 10 longitudinal analyses were included. Twenty-one studies met all MMAT quality criteria. We report a narrative synthesis due to the heterogeneity of the included studies. In CSF-based or blood-based assays or imaging, five out of six cross-sectional analyses found that AoHL was associated with elevated in vivo tau levels, whilst four out of 17 reported a link with elevated in vivo β-amyloid measures. One longitudinal analysis identified an association between AoHL and a steeper increase of CSF tau, but not Aβ , levels over time. Twenty-five out of 44 cross-sectional and six out of nine longitudinal analyses identified associations between AoHL and grey matter atrophy of the temporal regions, particularly the medial temporal lobe. Studies using other biomarkers had inconsistent findings. AoHL was usually associated with more temporal regions grey matter atrophy both cross-sectionally and longitudinally, and elevated in vivo tau but not β-amyloid. Increasing atrophy and higher tau, leading to decreased cognitive reserve may be how hearing loss increases dementia risk. |
| ArticleNumber | 102647 |
| Author | Omar, Rohani Sheppard, Jack Schilder, Anne G.M. Lasica, Aleksandra B. Yu, Ruan-Ching Costafreda, Sergi G. Livingston, Gill Ridgway, Nicola |
| Author_xml | – sequence: 1 givenname: Aleksandra B. surname: Lasica fullname: Lasica, Aleksandra B. email: aleksandra.lasica.13@ucl.ac.uk organization: NIHR University College London Hospitals Biomedical Research Centre, London, UK – sequence: 2 givenname: Jack surname: Sheppard fullname: Sheppard, Jack email: jack.sheppard.17@ucl.ac.uk organization: NIHR University College London Hospitals Biomedical Research Centre, London, UK – sequence: 3 givenname: Ruan-Ching orcidid: 0000-0002-8081-5300 surname: Yu fullname: Yu, Ruan-Ching email: ruan-ching.yu.18@ucl.ac.uk organization: Division of Psychiatry, University College London, Maple House, 149 Tottenham Court Road, London W1T 7NF, UK – sequence: 4 givenname: Gill surname: Livingston fullname: Livingston, Gill email: g.livingston@ucl.ac.uk organization: Division of Psychiatry, University College London, Maple House, 149 Tottenham Court Road, London W1T 7NF, UK – sequence: 5 givenname: Nicola surname: Ridgway fullname: Ridgway, Nicola email: n.ridgway@ucl.ac.uk organization: NIHR University College London Hospitals Biomedical Research Centre, London, UK – sequence: 6 givenname: Rohani surname: Omar fullname: Omar, Rohani email: rohani.omar@ucl.ac.uk organization: NIHR University College London Hospitals Biomedical Research Centre, London, UK – sequence: 7 givenname: Anne G.M. surname: Schilder fullname: Schilder, Anne G.M. email: a.schilder@ucl.ac.uk organization: NIHR University College London Hospitals Biomedical Research Centre, London, UK – sequence: 8 givenname: Sergi G. surname: Costafreda fullname: Costafreda, Sergi G. email: s.costafreda@ucl.ac.uk organization: Division of Psychiatry, University College London, Maple House, 149 Tottenham Court Road, London W1T 7NF, UK |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39746404$$D View this record in MEDLINE/PubMed |
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| Keywords | Tau Biomarker Amyloid Hearing Loss Cerebral Atrophy Dementia |
| Language | English |
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| Title | Association between adult-onset hearing loss and dementia biomarkers: A systematic review |
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