The preclinical gap in pancreatic cancer and radiotherapy

Pancreatic ductal adenocarcinoma is an aggressive malignancy with limited treatment options. Chemotherapy offers little benefit and, although there is some evidence that radiotherapy may improve response, its use in the clinical management of pancreatic cancer remains controversial due to conflictin...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Disease models & mechanisms Ročník 17; číslo 7
Hlavní autori: Tesson, Mathias, Morton, Jennifer P.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England The Company of Biologists Ltd 01.07.2024
The Company of Biologists
Predmet:
Animals
Humans
pancreatic cancer
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - radiotherapy
preclinical research
radiotherapy
Signal Transduction
Tumor Microenvironment - radiation effects
Radiotherapy
Pancreatic cancer
Preclinical research
ISSN:1754-8403, 1754-8411, 1754-8411
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Pancreatic ductal adenocarcinoma is an aggressive malignancy with limited treatment options. Chemotherapy offers little benefit and, although there is some evidence that radiotherapy may improve response, its use in the clinical management of pancreatic cancer remains controversial due to conflicting reports on its survival benefit. There has also been a lack of clinical trials that directly investigate the efficacy of radiotherapy in pancreatic cancer. The limited progress in the development of radiotherapeutic strategies in pancreatic cancer can be attributed, at least in part, to a dearth of preclinical research and our limited understanding of the effects of radiation on the pancreatic tumour microenvironment. In this Perspective, we discuss how insight into the immunosuppressive tumour microenvironment and the complex signalling between tumour and stromal cells following radiation is needed to develop effective radiosensitising strategies for pancreatic cancer. We also highlight that to have the best chance for successful clinical translation, more preclinical research is required in appropriately complex models.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
The authors declare no competing or financial interests.
Competing interests
ISSN:1754-8403
1754-8411
1754-8411
DOI:10.1242/dmm.050703