KLRG1 negatively regulates natural killer cell functions through the Akt pathway in individuals with chronic hepatitis C virus infection

In this study, we demonstrate that killer cell lectin-like receptor subfamily G member 1 (KLRG1), a transmembrane protein preferentially expressed on T cells, is highly expressed on CD56(+) NK cells, which are significantly reduced in their numbers and functions in the peripheral blood of patients w...

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Vydáno v:	Journal of virology Ročník 87; číslo 21; s. 11626
Hlavní autoři:	Wang, Jia M, Cheng, Yong Q, Shi, Lei, Ying, Ruo S, Wu, Xiao Y, Li, Guang Y, Moorman, Jonathan P, Yao, Zhi Q
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.11.2013
Témata:	Apoptosis CD56 Antigen - analysis Cell Proliferation Female Hepatitis C, Chronic - immunology Humans Interferon-gamma - secretion Killer Cells, Natural - chemistry Killer Cells, Natural - immunology Lectins, C-Type - metabolism Male Signal Transduction Trans-Activators - metabolism
ISSN:	1098-5514, 1098-5514
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