Classification of the glyphosate target enzyme (5-enolpyruvylshikimate-3-phosphate synthase) for assessing sensitivity of organisms to the herbicide

Glyphosate is the most common broad-spectrum herbicide. It targets the key enzyme of the shikimate pathway, 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), which synthesizes three essential aromatic amino acids (phenylalanine, tyrosine and tryptophan) in plants. Because the shikimate pathway is...

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Vydáno v:	Journal of hazardous materials Ročník 408; s. 124556
Hlavní autoři:	Leino, Lyydia, Tall, Tuomas, Helander, Marjo, Saloniemi, Irma, Saikkonen, Kari, Ruuskanen, Suvi, Puigbò, Pere
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier B.V 15.04.2021
Témata:	3-phosphoshikimate 1-carboxyvinyltransferase 3-Phosphoshikimate 1-Carboxyvinyltransferase - genetics bioinformatics Bioinformatics resource Biomarkers data collection Epsps enzyme eukaryotic cells Gastrointestinal Microbiome - drug effects Glycine - analogs & derivatives Glycine - toxicity Glyphosate Herbicide Herbicides - toxicity Humans intestinal microorganisms Microbiome phenylalanine prokaryotic cells Resistance Sensitivity Shikimate pathway tryptophan tyrosine Resistance Shikimate pathway Sensitivity Epsps enzyme Biomarkers Bioinformatics resource Glyphosate Herbicide Microbiome
ISSN:	0304-3894, 1873-3336, 1873-3336
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Abstract	Glyphosate is the most common broad-spectrum herbicide. It targets the key enzyme of the shikimate pathway, 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), which synthesizes three essential aromatic amino acids (phenylalanine, tyrosine and tryptophan) in plants. Because the shikimate pathway is also found in many prokaryotes and fungi, the widespread use of glyphosate may have unsuspected impacts on the diversity and composition of microbial communities, including the human gut microbiome. Here, we introduce the first bioinformatics method to assess the potential sensitivity of organisms to glyphosate based on the type of EPSPS enzyme. We have precomputed a dataset of EPSPS sequences from thousands of species that will be an invaluable resource to advancing the research field. This novel methodology can classify sequences from nearly 90% of eukaryotes and >80% of prokaryotes. A conservative estimate from our results shows that 54% of species in the core human gut microbiome are sensitive to glyphosate. [Display omitted] •We classify the target enzyme of the most common broad-spectrum herbicide.•The EPSPS enzyme can be classified in sensitive or resistant to glyphosate.•We introduce the first bioinformatics method to assess potential sensitivity to glyphosate.•Glyphosate may have an impact on half of the species in the core human gut microbiome.
AbstractList	Glyphosate is the most common broad-spectrum herbicide. It targets the key enzyme of the shikimate pathway, 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), which synthesizes three essential aromatic amino acids (phenylalanine, tyrosine and tryptophan) in plants. Because the shikimate pathway is also found in many prokaryotes and fungi, the widespread use of glyphosate may have unsuspected impacts on the diversity and composition of microbial communities, including the human gut microbiome. Here, we introduce the first bioinformatics method to assess the potential sensitivity of organisms to glyphosate based on the type of EPSPS enzyme. We have precomputed a dataset of EPSPS sequences from thousands of species that will be an invaluable resource to advancing the research field. This novel methodology can classify sequences from nearly 90% of eukaryotes and >80% of prokaryotes. A conservative estimate from our results shows that 54% of species in the core human gut microbiome are sensitive to glyphosate.Glyphosate is the most common broad-spectrum herbicide. It targets the key enzyme of the shikimate pathway, 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), which synthesizes three essential aromatic amino acids (phenylalanine, tyrosine and tryptophan) in plants. Because the shikimate pathway is also found in many prokaryotes and fungi, the widespread use of glyphosate may have unsuspected impacts on the diversity and composition of microbial communities, including the human gut microbiome. Here, we introduce the first bioinformatics method to assess the potential sensitivity of organisms to glyphosate based on the type of EPSPS enzyme. We have precomputed a dataset of EPSPS sequences from thousands of species that will be an invaluable resource to advancing the research field. This novel methodology can classify sequences from nearly 90% of eukaryotes and >80% of prokaryotes. A conservative estimate from our results shows that 54% of species in the core human gut microbiome are sensitive to glyphosate. Glyphosate is the most common broad-spectrum herbicide. It targets the key enzyme of the shikimate pathway, 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), which synthesizes three essential aromatic amino acids (phenylalanine, tyrosine and tryptophan) in plants. Because the shikimate pathway is also found in many prokaryotes and fungi, the widespread use of glyphosate may have unsuspected impacts on the diversity and composition of microbial communities, including the human gut microbiome. Here, we introduce the first bioinformatics method to assess the potential sensitivity of organisms to glyphosate based on the type of EPSPS enzyme. We have precomputed a dataset of EPSPS sequences from thousands of species that will be an invaluable resource to advancing the research field. This novel methodology can classify sequences from nearly 90% of eukaryotes and >80% of prokaryotes. A conservative estimate from our results shows that 54% of species in the core human gut microbiome are sensitive to glyphosate. Glyphosate is the most common broad-spectrum herbicide. It targets the key enzyme of the shikimate pathway, 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), which synthesizes three essential aromatic amino acids (phenylalanine, tyrosine and tryptophan) in plants. Because the shikimate pathway is also found in many prokaryotes and fungi, the widespread use of glyphosate may have unsuspected impacts on the diversity and composition of microbial communities, including the human gut microbiome. Here, we introduce the first bioinformatics method to assess the potential sensitivity of organisms to glyphosate based on the type of EPSPS enzyme. We have precomputed a dataset of EPSPS sequences from thousands of species that will be an invaluable resource to advancing the research field. This novel methodology can classify sequences from nearly 90% of eukaryotes and >80% of prokaryotes. A conservative estimate from our results shows that 54% of species in the core human gut microbiome are sensitive to glyphosate. [Display omitted] •We classify the target enzyme of the most common broad-spectrum herbicide.•The EPSPS enzyme can be classified in sensitive or resistant to glyphosate.•We introduce the first bioinformatics method to assess potential sensitivity to glyphosate.•Glyphosate may have an impact on half of the species in the core human gut microbiome.
ArticleNumber	124556
Author	Tall, Tuomas Saloniemi, Irma Ruuskanen, Suvi Leino, Lyydia Saikkonen, Kari Helander, Marjo Puigbò, Pere
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Cites_doi	10.1002/ps.4624 10.1016/S0022-2836(05)80360-2 10.1093/femsle/fnaa050 10.1016/j.etap.2018.12.019 10.1002/ps.4466 10.3109/10409239009090615 10.1093/nar/gks1195 10.1016/0006-291X(80)90547-1 10.1093/nar/gku1223 10.1007/978-1-4939-7000-1_26 10.1016/J.ENG.2017.01.008 10.1128/mBio.00009-15 10.1603/0046-225X-31.6.1206 10.1016/j.bjm.2016.10.005 10.1186/s12940-016-0117-0 10.1038/nature08821 10.1093/oxfordjournals.molbev.a026334 10.1093/nar/gkw1099 10.1093/nar/gkh340 10.1016/j.envpol.2016.07.019 10.1021/acs.biochem.5b00553 10.1093/nar/gkv1344 10.7717/peerj.5801 10.1002/ps.4652 10.1016/j.tplants.2012.05.008 10.1016/j.febslet.2004.12.057 10.1016/j.biotechadv.2018.10.007 10.1016/j.scitotenv.2018.05.377 10.1002/ps.4760 10.1073/pnas.0603638103 10.1128/EC.00106-06 10.1073/pnas.1803880115 10.1002/ps.3743 10.1038/nm.4517 10.1126/science.278.5338.631 10.1111/j.1742-4658.2011.08214.x 10.1074/jbc.M809771200 10.1016/j.tplants.2016.01.003 10.1038/s41598-020-67538-w 10.1007/s00284-012-0277-2 10.1371/journal.pone.0009490 10.1093/nar/gky995
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Keywords	Resistance Shikimate pathway Sensitivity Epsps enzyme Biomarkers Bioinformatics resource Glyphosate Herbicide Microbiome
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References	Light, Krishna, Minasov, Anderson (bib29) 2016; 55 Motta, Raymann, Moran (bib32) 2018; 115 Gilbert, Blaser, Caporaso, Jansson, Lynch, Knight (bib19) 2018; 24 Duke (bib11) 2017; 73 Sammons, Gaines (bib43) 2014; 70 Wang, Yao, Lv, Ling, Li (bib49) 2017; 3 Myers, Antoniou, Blumberg, Carroll, Colborn, Everett (bib33) 2016; 15 Braga, Dourado, Araújo (bib5) 2016; 47 Benson, Cavanaugh, Clark, Karsch-Mizrachi, Lipman, Ostell (bib3) 2013; 41 Helander, Saloniemi, Saikkonen (bib25) 2012; 17 Kurenbach, Marjoshi, Amábile-Cuevas, Ferguson, Godsoe, Gibson (bib28) 2015; 6 Richards, Dacks, Campbell, Blanchard, Foster, McLeod (bib42) 2006; 5 El-Gebali, Mistry, Bateman, Eddy, Luciani, Potter (bib13) 2019; 47 The UniProt Consortium (bib48) 2017; 45 Priestman, Funke, Singh, Crupper, Schönbrunn (bib39) 2005; 579 R: The R Project for Statistical Computing, n.d. Firdous, Iqbal, Anwar, Jabeen (bib15) 2018; 74 Pollegioni, Schonbrunn, Siehl (bib37) 2011; 278 Morjan, Pedigo, Lewis (bib31) 2002; 31 Bentley (bib4) 1990; 25 Nerozzi, Recuero, Galeati, Bucci, Spinaci, Yeste (bib35) 2020; 10 Altschul, Gish, Miller, Myers, Lipman (bib1) 1990; 215 Shehata, Schrödl, Aldin, Hafez, Krüger (bib44) 2013; 66 van Overbeek, Saikkonen (bib36) 2016; 21 Castresana (bib9) 2000; 17 Price, Dehal, Arkin (bib38) 2010; 5 Steinrücken, Amrhein (bib45) 1980; 94 Heap, Duke (bib22) 2018; 74 The International Service for the Acquisition of Agri-biotech Applications (ISAAA), (Ed.), 2017 Global Status of Commercialized Biotech/GM Crops in 2017: Biotech Crop Adoption Surges Aseconomic Benefits Accumulate in 22 Years. ISAAA, Ithaca, NY. Burley, Berman, Kleywegt, Markley, Nakamura, Velankar (bib7) 2017; 1607 Carozzi, N., Carr, B., Hammer, P., 2006. US20060253921A1 - Identification of a new class of EPSP synthases, US20060253921A1. Qin, Li, Raes, Arumugam, Burgdorf, Manichanh (bib40) 2010; 464 (Accessed 9 April 2018). Burchfield, Bailey, Todt, Denney, Negga, Fitsanakis (bib6) 2019; 66 Galperin, Makarova, Wolf, Koonin (bib18) 2015; 43 Funke, Yang, Han, Healy-Fried, Olesen, Becker (bib17) 2009; 284 Juturu, Wu (bib26) 2018; 36 Finn, Coggill, Eberhardt, Eddy, Mistry, Mitchell (bib14) 2016; 44 Barry, G.F., Kishore, G.M., Padgette, S.R., Stallings, W.C., 1997. US5627061A - Glyphosate-tolerant 5-enolpyruvylshikimate-3-phosphate synthases, US5627061A. Tatusov, Koonin, Lipman (bib46) 1997; 278 Duke (bib10) 2018; 74 Gomes, Juneau (bib20) 2016; 218 Edgar (bib12) 2004; 32 Kurenbach, Hill, Godsoe, van Hamelsveld, Heinemann (bib27) 2018; 6 Helander, Saloniemi, Omacini, Druille, Salminen, Saikkonen (bib24) 2018; 642 Lira, J.M., Cicchillo, R.M., Nair, S.K., 2013. US20130217577A1 - Novel class of glyphosate resistance genes, US20130217577A1. (bib34) 2010 Gómez-Gallego, Rainio, Collado, Mantziari, Salminen, Saikkonen (bib21) 2020; 367 Heap, I., n.a. The International Survey of Herbicide Resistant Weeds. Funke, Han, Healy-Fried, Fischer, Schönbrunn (bib16) 2006; 103 Gomes (10.1016/j.jhazmat.2020.124556_bib20) 2016; 218 Heap (10.1016/j.jhazmat.2020.124556_bib22) 2018; 74 10.1016/j.jhazmat.2020.124556_bib8 Gilbert (10.1016/j.jhazmat.2020.124556_bib19) 2018; 24 Priestman (10.1016/j.jhazmat.2020.124556_bib39) 2005; 579 Burley (10.1016/j.jhazmat.2020.124556_bib7) 2017; 1607 10.1016/j.jhazmat.2020.124556_bib2 10.1016/j.jhazmat.2020.124556_bib23 Shehata (10.1016/j.jhazmat.2020.124556_bib44) 2013; 66 Qin (10.1016/j.jhazmat.2020.124556_bib40) 2010; 464 Helander (10.1016/j.jhazmat.2020.124556_bib24) 2018; 642 El-Gebali (10.1016/j.jhazmat.2020.124556_bib13) 2019; 47 Altschul (10.1016/j.jhazmat.2020.124556_bib1) 1990; 215 Burchfield (10.1016/j.jhazmat.2020.124556_bib6) 2019; 66 Motta (10.1016/j.jhazmat.2020.124556_bib32) 2018; 115 Castresana (10.1016/j.jhazmat.2020.124556_bib9) 2000; 17 Nerozzi (10.1016/j.jhazmat.2020.124556_bib35) 2020; 10 Steinrücken (10.1016/j.jhazmat.2020.124556_bib45) 1980; 94 Morjan (10.1016/j.jhazmat.2020.124556_bib31) 2002; 31 Funke (10.1016/j.jhazmat.2020.124556_bib16) 2006; 103 Juturu (10.1016/j.jhazmat.2020.124556_bib26) 2018; 36 Gómez-Gallego (10.1016/j.jhazmat.2020.124556_bib21) 2020; 367 Price (10.1016/j.jhazmat.2020.124556_bib38) 2010; 5 Myers (10.1016/j.jhazmat.2020.124556_bib33) 2016; 15 Tatusov (10.1016/j.jhazmat.2020.124556_bib46) 1997; 278 The UniProt Consortium (10.1016/j.jhazmat.2020.124556_bib48) 2017; 45 Braga (10.1016/j.jhazmat.2020.124556_bib5) 2016; 47 Pollegioni (10.1016/j.jhazmat.2020.124556_bib37) 2011; 278 Kurenbach (10.1016/j.jhazmat.2020.124556_bib28) 2015; 6 Light (10.1016/j.jhazmat.2020.124556_bib29) 2016; 55 10.1016/j.jhazmat.2020.124556_bib47 Funke (10.1016/j.jhazmat.2020.124556_bib17) 2009; 284 van Overbeek (10.1016/j.jhazmat.2020.124556_bib36) 2016; 21 10.1016/j.jhazmat.2020.124556_bib41 Wang (10.1016/j.jhazmat.2020.124556_bib49) 2017; 3 Benson (10.1016/j.jhazmat.2020.124556_bib3) 2013; 41 Galperin (10.1016/j.jhazmat.2020.124556_bib18) 2015; 43 Duke (10.1016/j.jhazmat.2020.124556_bib11) 2017; 73 Helander (10.1016/j.jhazmat.2020.124556_bib25) 2012; 17 Bentley (10.1016/j.jhazmat.2020.124556_bib4) 1990; 25 Duke (10.1016/j.jhazmat.2020.124556_bib10) 2018; 74 Finn (10.1016/j.jhazmat.2020.124556_bib14) 2016; 44 Richards (10.1016/j.jhazmat.2020.124556_bib42) 2006; 5 10.1016/j.jhazmat.2020.124556_bib30 Sammons (10.1016/j.jhazmat.2020.124556_bib43) 2014; 70 (10.1016/j.jhazmat.2020.124556_bib34) 2010 Kurenbach (10.1016/j.jhazmat.2020.124556_bib27) 2018; 6 Firdous (10.1016/j.jhazmat.2020.124556_bib15) 2018; 74 Edgar (10.1016/j.jhazmat.2020.124556_bib12) 2004; 32
References_xml	– volume: 47 start-page: D427 year: 2019 end-page: D432 ident: bib13 article-title: The Pfam protein families database in 2019 publication-title: Nucleic Acids Res. – volume: 17 start-page: 540 year: 2000 end-page: 552 ident: bib9 article-title: Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis publication-title: Mol. Biol. Evol. – reference: R: The R Project for Statistical Computing, n.d. – volume: 1607 start-page: 627 year: 2017 end-page: 641 ident: bib7 article-title: Protein data bank (PDB): the single global macromolecular structure archive publication-title: Methods Mol. Biol. – reference: . (Accessed 9 April 2018). – year: 2010 ident: bib34 publication-title: Glyphosate Resistance in Crops and Weeds: History, Development, and Management – volume: 367 year: 2020 ident: bib21 article-title: Glyphosate-based herbicide affects the composition of microbes associated with Colorado potato beetle (Leptinotarsa decemlineata) publication-title: FEMS Microbiol. Lett. – volume: 73 start-page: 7 year: 2017 end-page: 8 ident: bib11 article-title: Summing up the past year for Pest Management Science publication-title: Pest Manag. Sci. – volume: 24 start-page: 392 year: 2018 end-page: 400 ident: bib19 article-title: Current understanding of the human microbiome publication-title: Nat. Med. – volume: 103 start-page: 13010 year: 2006 end-page: 13015 ident: bib16 article-title: Molecular basis for the herbicide resistance of Roundup Ready crops publication-title: Proc. Natl Acad. Sci. USA – volume: 115 start-page: 10305 year: 2018 end-page: 10310 ident: bib32 article-title: Glyphosate perturbs the gut microbiota of honey bees publication-title: Proc. Natl Acad. Sci. USA – volume: 45 start-page: D158 year: 2017 end-page: D169 ident: bib48 article-title: UniProt: the universal protein knowledgebase publication-title: Nucleic Acids Res. – reference: Barry, G.F., Kishore, G.M., Padgette, S.R., Stallings, W.C., 1997. US5627061A - Glyphosate-tolerant 5-enolpyruvylshikimate-3-phosphate synthases, US5627061A. – volume: 10 start-page: 11026 year: 2020 ident: bib35 article-title: Effects of roundup and its main component, glyphosate, upon mammalian sperm function and survival publication-title: Sci. Rep. – volume: 278 start-page: 2753 year: 2011 end-page: 2766 ident: bib37 article-title: Molecular basis of glyphosate resistance-different approaches through protein engineering publication-title: FEBS J. – volume: 218 start-page: 402 year: 2016 end-page: 409 ident: bib20 article-title: Oxidative stress in duckweed (Lemna minor L.) induced by glyphosate: Is the mitochondrial electron transport chain a target of this herbicide? publication-title: Environ. Pollut. – volume: 15 start-page: 19 year: 2016 ident: bib33 article-title: Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement publication-title: Environ. Health – volume: 74 start-page: 1027 year: 2018 end-page: 1034 ident: bib10 article-title: The history and current status of glyphosate publication-title: Pest Manag. Sci. – volume: 215 start-page: 403 year: 1990 end-page: 410 ident: bib1 article-title: Basic local alignment search tool publication-title: J. Mol. Biol. – reference: The International Service for the Acquisition of Agri-biotech Applications (ISAAA), (Ed.), 2017 Global Status of Commercialized Biotech/GM Crops in 2017: Biotech Crop Adoption Surges Aseconomic Benefits Accumulate in 22 Years. ISAAA, Ithaca, NY. – volume: 6 year: 2015 ident: bib28 article-title: Sublethal exposure to commercial formulations of the herbicides dicamba, 2,4-dichlorophenoxyacetic acid, and glyphosate cause changes in antibiotic susceptibility in Escherichia coli and Salmonella enterica serovar Typhimurium publication-title: MBio – volume: 642 start-page: 285 year: 2018 end-page: 291 ident: bib24 article-title: Glyphosate decreases mycorrhizal colonization and affects plant-soil feedback publication-title: Sci. Total Environ. – volume: 464 start-page: 59 year: 2010 end-page: 65 ident: bib40 article-title: A human gut microbial gene catalogue established by metagenomic sequencing publication-title: Nature – volume: 43 start-page: D261 year: 2015 end-page: 9 ident: bib18 article-title: Expanded microbial genome coverage and improved protein family annotation in the COG database publication-title: Nucleic Acids Res. – volume: 70 start-page: 1367 year: 2014 end-page: 1377 ident: bib43 article-title: Glyphosate resistance: state of knowledge publication-title: Pest Manag. Sci. – volume: 21 start-page: 230 year: 2016 end-page: 242 ident: bib36 article-title: Impact of bacterial-fungal interactions on the colonization of the endosphere publication-title: Trends Plant Sci. – volume: 6 year: 2018 ident: bib27 article-title: Agrichemicals and antibiotics in combination increase antibiotic resistance evolution publication-title: PeerJ – volume: 278 start-page: 631 year: 1997 end-page: 637 ident: bib46 article-title: A genomic perspective on protein families publication-title: Science – volume: 284 start-page: 9854 year: 2009 end-page: 9860 ident: bib17 article-title: Structural basis of glyphosate resistance resulting from the double mutation Thr97 -> Ile and Pro101 -> Ser in 5-enolpyruvylshikimate-3-phosphate synthase from Escherichia coli publication-title: J. Biol. Chem. – reference: Carozzi, N., Carr, B., Hammer, P., 2006. US20060253921A1 - Identification of a new class of EPSP synthases, US20060253921A1. – volume: 17 start-page: 569 year: 2012 end-page: 574 ident: bib25 article-title: Glyphosate in northern ecosystems publication-title: Trends Plant Sci. – volume: 32 start-page: 1792 year: 2004 end-page: 1797 ident: bib12 article-title: MUSCLE: multiple sequence alignment with high accuracy and high throughput publication-title: Nucleic Acids Res. – volume: 25 start-page: 307 year: 1990 end-page: 384 ident: bib4 article-title: The shikimate pathway--a metabolic tree with many branches publication-title: Crit. Rev. Biochem. Mol. Biol. – volume: 5 start-page: 1517 year: 2006 end-page: 1531 ident: bib42 article-title: Evolutionary origins of the eukaryotic shikimate pathway: gene fusions, horizontal gene transfer, and endosymbiotic replacements publication-title: Eukaryot. Cell – volume: 94 start-page: 1207 year: 1980 end-page: 1212 ident: bib45 article-title: The herbicide glyphosate is a potent inhibitor of 5-enolpyruvylshikimic acid-3-phosphate synthase publication-title: Biochem. Biophys. Res. Commun. – volume: 74 start-page: 1040 year: 2018 end-page: 1049 ident: bib22 article-title: Overview of glyphosate-resistant weeds worldwide publication-title: Pest Manag. Sci. – volume: 41 start-page: D36 year: 2013 end-page: 42 ident: bib3 article-title: GenBank publication-title: Nucleic Acids Res. – volume: 74 start-page: 1184 year: 2018 end-page: 1196 ident: bib15 article-title: Identification and analysis of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene from glyphosate-resistant Ochrobactrum intermedium Sq20 publication-title: Pest Manag. Sci. – volume: 66 start-page: 36 year: 2019 end-page: 42 ident: bib6 article-title: Acute exposure to a glyphosate-containing herbicide formulation inhibits Complex II and increases hydrogen peroxide in the model organism Caenorhabditis elegans publication-title: Environ. Toxicol. Pharmacol. – volume: 579 start-page: 728 year: 2005 end-page: 732 ident: bib39 article-title: 5-Enolpyruvylshikimate-3-phosphate synthase from Staphylococcus aureus is insensitive to glyphosate publication-title: FEBS Lett. – volume: 47 start-page: 86 year: 2016 end-page: 98 ident: bib5 article-title: Microbial interactions: ecology in a molecular perspective publication-title: Braz. J. Microbiol. – volume: 36 start-page: 2187 year: 2018 end-page: 2200 ident: bib26 article-title: Microbial production of bacteriocins: latest research development and applications publication-title: Biotechnol. Adv. – reference: Lira, J.M., Cicchillo, R.M., Nair, S.K., 2013. US20130217577A1 - Novel class of glyphosate resistance genes, US20130217577A1. – volume: 3 start-page: 71 year: 2017 end-page: 82 ident: bib49 article-title: The human microbiota in health and disease publication-title: Engineering – reference: Heap, I., n.a. The International Survey of Herbicide Resistant Weeds. – volume: 31 start-page: 1206 year: 2002 end-page: 1212 ident: bib31 article-title: Fungicidal effects of glyphosate and glyphosate formulations on four species of entomopathogenic fungi publication-title: Environ. Entomol. – volume: 5 year: 2010 ident: bib38 article-title: FastTree 2 — approximately maximum-likelihood trees for large alignments publication-title: PLoS ONE – volume: 55 start-page: 1239 year: 2016 end-page: 1245 ident: bib29 article-title: An unusual cation-binding site and distinct domain-domain interactions distinguish class II enolpyruvylshikimate-3-phosphate synthases publication-title: Biochemistry – volume: 44 start-page: D279 year: 2016 end-page: 85 ident: bib14 article-title: The Pfam protein families database: towards a more sustainable future publication-title: Nucleic Acids Res. – volume: 66 start-page: 350 year: 2013 end-page: 358 ident: bib44 article-title: The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro publication-title: Curr. Microbiol. – volume: 74 start-page: 1184 year: 2018 ident: 10.1016/j.jhazmat.2020.124556_bib15 article-title: Identification and analysis of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene from glyphosate-resistant Ochrobactrum intermedium Sq20 publication-title: Pest Manag. Sci. doi: 10.1002/ps.4624 – volume: 215 start-page: 403 year: 1990 ident: 10.1016/j.jhazmat.2020.124556_bib1 article-title: Basic local alignment search tool publication-title: J. Mol. Biol. doi: 10.1016/S0022-2836(05)80360-2 – volume: 367 year: 2020 ident: 10.1016/j.jhazmat.2020.124556_bib21 article-title: Glyphosate-based herbicide affects the composition of microbes associated with Colorado potato beetle (Leptinotarsa decemlineata) publication-title: FEMS Microbiol. Lett. doi: 10.1093/femsle/fnaa050 – volume: 66 start-page: 36 year: 2019 ident: 10.1016/j.jhazmat.2020.124556_bib6 article-title: Acute exposure to a glyphosate-containing herbicide formulation inhibits Complex II and increases hydrogen peroxide in the model organism Caenorhabditis elegans publication-title: Environ. Toxicol. Pharmacol. doi: 10.1016/j.etap.2018.12.019 – volume: 73 start-page: 7 year: 2017 ident: 10.1016/j.jhazmat.2020.124556_bib11 article-title: Summing up the past year for Pest Management Science publication-title: Pest Manag. Sci. doi: 10.1002/ps.4466 – volume: 25 start-page: 307 year: 1990 ident: 10.1016/j.jhazmat.2020.124556_bib4 article-title: The shikimate pathway--a metabolic tree with many branches publication-title: Crit. Rev. Biochem. Mol. Biol. doi: 10.3109/10409239009090615 – volume: 41 start-page: D36 year: 2013 ident: 10.1016/j.jhazmat.2020.124556_bib3 article-title: GenBank publication-title: Nucleic Acids Res. doi: 10.1093/nar/gks1195 – volume: 94 start-page: 1207 year: 1980 ident: 10.1016/j.jhazmat.2020.124556_bib45 article-title: The herbicide glyphosate is a potent inhibitor of 5-enolpyruvylshikimic acid-3-phosphate synthase publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/0006-291X(80)90547-1 – volume: 43 start-page: D261 year: 2015 ident: 10.1016/j.jhazmat.2020.124556_bib18 article-title: Expanded microbial genome coverage and improved protein family annotation in the COG database publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku1223 – ident: 10.1016/j.jhazmat.2020.124556_bib23 – ident: 10.1016/j.jhazmat.2020.124556_bib41 – year: 2010 ident: 10.1016/j.jhazmat.2020.124556_bib34 – volume: 1607 start-page: 627 year: 2017 ident: 10.1016/j.jhazmat.2020.124556_bib7 article-title: Protein data bank (PDB): the single global macromolecular structure archive publication-title: Methods Mol. Biol. doi: 10.1007/978-1-4939-7000-1_26 – volume: 3 start-page: 71 year: 2017 ident: 10.1016/j.jhazmat.2020.124556_bib49 article-title: The human microbiota in health and disease publication-title: Engineering doi: 10.1016/J.ENG.2017.01.008 – volume: 6 year: 2015 ident: 10.1016/j.jhazmat.2020.124556_bib28 article-title: Sublethal exposure to commercial formulations of the herbicides dicamba, 2,4-dichlorophenoxyacetic acid, and glyphosate cause changes in antibiotic susceptibility in Escherichia coli and Salmonella enterica serovar Typhimurium publication-title: MBio doi: 10.1128/mBio.00009-15 – volume: 31 start-page: 1206 year: 2002 ident: 10.1016/j.jhazmat.2020.124556_bib31 article-title: Fungicidal effects of glyphosate and glyphosate formulations on four species of entomopathogenic fungi publication-title: Environ. Entomol. doi: 10.1603/0046-225X-31.6.1206 – volume: 47 start-page: 86 issue: Suppl 1 year: 2016 ident: 10.1016/j.jhazmat.2020.124556_bib5 article-title: Microbial interactions: ecology in a molecular perspective publication-title: Braz. J. Microbiol. doi: 10.1016/j.bjm.2016.10.005 – volume: 15 start-page: 19 year: 2016 ident: 10.1016/j.jhazmat.2020.124556_bib33 article-title: Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement publication-title: Environ. Health doi: 10.1186/s12940-016-0117-0 – volume: 464 start-page: 59 year: 2010 ident: 10.1016/j.jhazmat.2020.124556_bib40 article-title: A human gut microbial gene catalogue established by metagenomic sequencing publication-title: Nature doi: 10.1038/nature08821 – ident: 10.1016/j.jhazmat.2020.124556_bib30 – ident: 10.1016/j.jhazmat.2020.124556_bib2 – volume: 17 start-page: 540 year: 2000 ident: 10.1016/j.jhazmat.2020.124556_bib9 article-title: Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis publication-title: Mol. Biol. Evol. doi: 10.1093/oxfordjournals.molbev.a026334 – volume: 45 start-page: D158 year: 2017 ident: 10.1016/j.jhazmat.2020.124556_bib48 article-title: UniProt: the universal protein knowledgebase publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkw1099 – volume: 32 start-page: 1792 year: 2004 ident: 10.1016/j.jhazmat.2020.124556_bib12 article-title: MUSCLE: multiple sequence alignment with high accuracy and high throughput publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkh340 – volume: 218 start-page: 402 year: 2016 ident: 10.1016/j.jhazmat.2020.124556_bib20 article-title: Oxidative stress in duckweed (Lemna minor L.) induced by glyphosate: Is the mitochondrial electron transport chain a target of this herbicide? publication-title: Environ. Pollut. doi: 10.1016/j.envpol.2016.07.019 – volume: 55 start-page: 1239 year: 2016 ident: 10.1016/j.jhazmat.2020.124556_bib29 article-title: An unusual cation-binding site and distinct domain-domain interactions distinguish class II enolpyruvylshikimate-3-phosphate synthases publication-title: Biochemistry doi: 10.1021/acs.biochem.5b00553 – volume: 44 start-page: D279 year: 2016 ident: 10.1016/j.jhazmat.2020.124556_bib14 article-title: The Pfam protein families database: towards a more sustainable future publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv1344 – volume: 6 year: 2018 ident: 10.1016/j.jhazmat.2020.124556_bib27 article-title: Agrichemicals and antibiotics in combination increase antibiotic resistance evolution publication-title: PeerJ doi: 10.7717/peerj.5801 – volume: 74 start-page: 1027 year: 2018 ident: 10.1016/j.jhazmat.2020.124556_bib10 article-title: The history and current status of glyphosate publication-title: Pest Manag. Sci. doi: 10.1002/ps.4652 – volume: 17 start-page: 569 year: 2012 ident: 10.1016/j.jhazmat.2020.124556_bib25 article-title: Glyphosate in northern ecosystems publication-title: Trends Plant Sci. doi: 10.1016/j.tplants.2012.05.008 – volume: 579 start-page: 728 year: 2005 ident: 10.1016/j.jhazmat.2020.124556_bib39 article-title: 5-Enolpyruvylshikimate-3-phosphate synthase from Staphylococcus aureus is insensitive to glyphosate publication-title: FEBS Lett. doi: 10.1016/j.febslet.2004.12.057 – volume: 36 start-page: 2187 year: 2018 ident: 10.1016/j.jhazmat.2020.124556_bib26 article-title: Microbial production of bacteriocins: latest research development and applications publication-title: Biotechnol. Adv. doi: 10.1016/j.biotechadv.2018.10.007 – volume: 642 start-page: 285 year: 2018 ident: 10.1016/j.jhazmat.2020.124556_bib24 article-title: Glyphosate decreases mycorrhizal colonization and affects plant-soil feedback publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2018.05.377 – volume: 74 start-page: 1040 year: 2018 ident: 10.1016/j.jhazmat.2020.124556_bib22 article-title: Overview of glyphosate-resistant weeds worldwide publication-title: Pest Manag. Sci. doi: 10.1002/ps.4760 – volume: 103 start-page: 13010 year: 2006 ident: 10.1016/j.jhazmat.2020.124556_bib16 article-title: Molecular basis for the herbicide resistance of Roundup Ready crops publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0603638103 – volume: 5 start-page: 1517 year: 2006 ident: 10.1016/j.jhazmat.2020.124556_bib42 article-title: Evolutionary origins of the eukaryotic shikimate pathway: gene fusions, horizontal gene transfer, and endosymbiotic replacements publication-title: Eukaryot. Cell doi: 10.1128/EC.00106-06 – volume: 115 start-page: 10305 year: 2018 ident: 10.1016/j.jhazmat.2020.124556_bib32 article-title: Glyphosate perturbs the gut microbiota of honey bees publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1803880115 – volume: 70 start-page: 1367 year: 2014 ident: 10.1016/j.jhazmat.2020.124556_bib43 article-title: Glyphosate resistance: state of knowledge publication-title: Pest Manag. Sci. doi: 10.1002/ps.3743 – volume: 24 start-page: 392 year: 2018 ident: 10.1016/j.jhazmat.2020.124556_bib19 article-title: Current understanding of the human microbiome publication-title: Nat. Med. doi: 10.1038/nm.4517 – volume: 278 start-page: 631 year: 1997 ident: 10.1016/j.jhazmat.2020.124556_bib46 article-title: A genomic perspective on protein families publication-title: Science doi: 10.1126/science.278.5338.631 – volume: 278 start-page: 2753 year: 2011 ident: 10.1016/j.jhazmat.2020.124556_bib37 article-title: Molecular basis of glyphosate resistance-different approaches through protein engineering publication-title: FEBS J. doi: 10.1111/j.1742-4658.2011.08214.x – volume: 284 start-page: 9854 year: 2009 ident: 10.1016/j.jhazmat.2020.124556_bib17 article-title: Structural basis of glyphosate resistance resulting from the double mutation Thr97 -> Ile and Pro101 -> Ser in 5-enolpyruvylshikimate-3-phosphate synthase from Escherichia coli publication-title: J. Biol. Chem. doi: 10.1074/jbc.M809771200 – ident: 10.1016/j.jhazmat.2020.124556_bib47 – volume: 21 start-page: 230 year: 2016 ident: 10.1016/j.jhazmat.2020.124556_bib36 article-title: Impact of bacterial-fungal interactions on the colonization of the endosphere publication-title: Trends Plant Sci. doi: 10.1016/j.tplants.2016.01.003 – volume: 10 start-page: 11026 year: 2020 ident: 10.1016/j.jhazmat.2020.124556_bib35 article-title: Effects of roundup and its main component, glyphosate, upon mammalian sperm function and survival publication-title: Sci. Rep. doi: 10.1038/s41598-020-67538-w – volume: 66 start-page: 350 year: 2013 ident: 10.1016/j.jhazmat.2020.124556_bib44 article-title: The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro publication-title: Curr. Microbiol. doi: 10.1007/s00284-012-0277-2 – volume: 5 year: 2010 ident: 10.1016/j.jhazmat.2020.124556_bib38 article-title: FastTree 2 — approximately maximum-likelihood trees for large alignments publication-title: PLoS ONE doi: 10.1371/journal.pone.0009490 – ident: 10.1016/j.jhazmat.2020.124556_bib8 – volume: 47 start-page: D427 year: 2019 ident: 10.1016/j.jhazmat.2020.124556_bib13 article-title: The Pfam protein families database in 2019 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky995
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SubjectTerms	3-phosphoshikimate 1-carboxyvinyltransferase 3-Phosphoshikimate 1-Carboxyvinyltransferase - genetics bioinformatics Bioinformatics resource Biomarkers data collection Epsps enzyme eukaryotic cells Gastrointestinal Microbiome - drug effects Glycine - analogs & derivatives Glycine - toxicity Glyphosate Herbicide Herbicides - toxicity Humans intestinal microorganisms Microbiome phenylalanine prokaryotic cells Resistance Sensitivity Shikimate pathway tryptophan tyrosine
Title	Classification of the glyphosate target enzyme (5-enolpyruvylshikimate-3-phosphate synthase) for assessing sensitivity of organisms to the herbicide
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