A Toxicological Evaluation of Chlamydomonas reinhardtii, a Green Algae

There is a current worldwide interest in developing novel sustainable nonanimal nutritional sources, and one such source is the green algae Chlamydomonas reinhardtii, the only green algae that has been studied as a model organism for many biological processes ranging from photosynthesis to flagellar...

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Veröffentlicht in:International journal of toxicology Jg. 37; H. 1; S. 53
Hauptverfasser: Murbach, Timothy S, Glávits, Róbert, Endres, John R, Hirka, Gábor, Vértesi, Adél, Béres, Erzsébet, Szakonyiné, Ilona Pasics
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.01.2018
Schlagworte:
Animals
Chlamydomonas reinhardtii - physiology
Dose-Response Relationship, Drug
Female
Food Safety
Humans
Male
Micronucleus Tests
No-Observed-Adverse-Effect Level
Rats
toxicity
algal biomass
mutagenicity
green algae
Chlamydomonas reinhardtii
safety
NOAEL
ISSN:1092-874X, 1092-874X
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Zusammenfassung:There is a current worldwide interest in developing novel sustainable nonanimal nutritional sources, and one such source is the green algae Chlamydomonas reinhardtii, the only green algae that has been studied as a model organism for many biological processes ranging from photosynthesis to flagellar movement. However, its potential as a safe nutritional source for use in various foods has not been thoroughly investigated. To assess the safety of C reinhardtii for use as a nutritional human food ingredient, in accordance with internationally accepted standards, the genotoxic potential and repeated-dose oral toxicity of the dried C reinhardtii (THN 6) algal biomass was investigated. The following studies were conducted: (1) a bacterial reverse mutation test, (2) an in vitro mammalian chromosomal aberration test, (3) an in vivo mammalian micronucleus test, and (4) a 28-day repeated-dose oral toxicity study in rats. No evidence of mutagenicity or genotoxic activity was observed in the first 3 tests under the applied test systems. In the 28-day study, male and female Hsd.Han Wistar rats were exposed to daily doses of 0, 1,000, 2,000, and 4,000 mg/kg bw by gavage. Following 28 days of continuous exposure, no mortality or treatment-related adverse effects were observed and no target organs were identified. Therefore, a no observed adverse effect level was concluded as 4,000 mg/kg bw/day, the highest dose tested.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1092-874X
1092-874X
DOI:10.1177/1091581817746109