Tunable release of hydrophilic compounds from hydrophobic nanostructured fibers prepared by emulsion electrospinning

The electrospinning process is a versatile technique for the encapsulation and controlled release of active substances. It also allows for the formation of various types of fiber microstructures such as porous or dense fibers, as well as core-sheath, co-continuous or hollow fibers. Herein, we aim at...

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Vydané v:Polymer (Guilford) Ročník 66; s. 268 - 276
Hlavní autori: Yazgan, G., Popa, A.M., Rossi, R.M., Maniura-Weber, K., Puigmartí-Luis, J., Crespy, D., Fortunato, G.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Elsevier Ltd 01.06.2015
Predmet:
Concentration (composition)
Electrospinning
Emulsion
Emulsions
Fibers
Morphology
Polystyrene resins
Porous fibers
Relative humidity
Release kinetics
Surfactants
Electrospinning
Emulsion
Porous fibers
Release kinetics
ISSN:0032-3861, 1873-2291
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Shrnutí:The electrospinning process is a versatile technique for the encapsulation and controlled release of active substances. It also allows for the formation of various types of fiber microstructures such as porous or dense fibers, as well as core-sheath, co-continuous or hollow fibers. Herein, we aim at studying and controlling the release kinetics of a model substance from electrospun fibers in function of their morphology and composition. In this regard, we incorporated fluorescein sodium salt (FLU) as a model compound in fibers that were composed of polystyrene (PS) and polyvinylpyrrolidone (PVP) by electrospinning of inverse emulsions. We studied the effect of electrospinning parameters such as the relative humidity (RH%) and the surfactant concentration on fiber morphology, surface chemistry, wettability, membrane architecture, and release kinetics. Moreover, we demonstrate that fast release rates can be obtained when an emulsion is electrospun with an optimized surfactant concentration and at high relative humidity conditions. Such a combination yielded highly porous fibers with an average diameter of 2.4 ± 0.7 μm with ribbon-like cross sections. However, when the surfactant concentration was increased, dense fibers exhibiting slower release behavior were obtained. These results are a step forward in the systematization and control of release kinetics for non-woven membranes produced from electrospun emulsions. We demonstrate that both an accurate control of the fiber microstructure as well as the fiber composition is important to tailor the release kinetics of a model compound. [Display omitted] •Fluorescein sodium salt was encapsulated within polystyrene fibers by emulsion e-spinning.•Relative humidities and surfactant concentrations were studied with respect to resulting fiber morphologies.•Porous fibers were obtained at high relative humidity conditions and low surfactant concentrations.•Release kinetics showed distinct influences regarding fiber morphologies.
Bibliografia:ObjectType-Article-1
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content type line 23
ISSN:0032-3861
1873-2291
DOI:10.1016/j.polymer.2015.04.045