Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer

After a median of nearly 4 years of follow-up, the use of radiotherapy combined with chemotherapy in patients with stage III or IVA endometrial carcinoma was not associated with longer relapse-free survival than the use of chemotherapy alone.

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Bibliographic Details
Published in:The New England journal of medicine Vol. 380; no. 24; pp. 2317 - 2326
Main Authors: Matei, Daniela, Filiaci, Virginia, Randall, Marcus E, Mutch, David, Steinhoff, Margaret M, DiSilvestro, Paul A, Moxley, Katherine M, Kim, Yong M, Powell, Matthew A, O’Malley, David M, Spirtos, Nick M, Small, William, Tewari, Krishnansu S, Richards, William E, Nakayama, John, Matulonis, Ursula A, Huang, Helen Q, Miller, David S
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 13.06.2019
Subjects:
Abdomen
Adjuvants
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer therapies
Carcinoma
Chemoradiotherapy
Chemoradiotherapy, Adjuvant
Chemotherapy
Chemotherapy, Adjuvant
Computer centers
Disease-Free Survival
Endometrial cancer
Endometrial Neoplasms - mortality
Endometrial Neoplasms - pathology
Endometrial Neoplasms - surgery
Endometrial Neoplasms - therapy
Endometrium
Female
Humans
Kaplan-Meier Estimate
Metastasis
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Neoplasm, Residual
Oncology
Patients
Platinum
Prognosis
Quality of Life
Radiation therapy
Recurrence
Statistics, Nonparametric
Survival
Treatment Outcome
Uterine cancer
Vagina
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:After a median of nearly 4 years of follow-up, the use of radiotherapy combined with chemotherapy in patients with stage III or IVA endometrial carcinoma was not associated with longer relapse-free survival than the use of chemotherapy alone.
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Address reprint requests to Dr. Matei at the Division of Gynecologic Oncology, Northwestern University, 303 E. Superior St., Lurie 4-107, Chicago, IL 60610, or at daniela.matei@northwestern.edu.
ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1813181