Toxic effect of alpha cypermethrin, an environmental pollutant, on myocardial tissue in male wistar rats

α-Cypermethrin (CYP) is a pyrethroid insecticide-like environmental pollutant, widely found in the environment. New research links exposure to high levels of CYP to health damage; however, little is known about the effect of CYP on cardiovascular disease. The purpose of the present study was to eval...

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Vydáno v:	Environmental science and pollution research international Ročník 27; číslo 6; s. 5709 - 5717
Hlavní autoři:	Ghazouani, Lakhdar, Feriani, Anouar, Mufti, Afoua, Tir, Meriam, Baaziz, Intissar, Mansour, Hedi Ben, Mnafgui, Kais
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2020 Springer Nature B.V
Témata:	Animals Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Calcium-binding protein Cardiotoxicity Cardiovascular diseases catalase Cholesterol Collagen Cypermethrin DNA fragmentation Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental Pollutants - toxicity Environmental Pollution Environmental science enzyme activity Food Contamination glutathione peroxidase Heart Heart - drug effects histology Insecticides laboratory animals Male males Myocardium - enzymology Oxidative Stress Pollutants pyrethrins Pyrethrins - toxicity Pyrethroids Rats Rats, Wistar Risk Assessment and Remediation Rodents staining superoxide dismutase Toxicity triacylglycerols Triglycerides Troponin troponin T Waste Water Technology Water Management Water Pollution Control Oxidative stress Histology Cardiotoxicity Sirius red Genomic DNA α-Cypermethrin
ISSN:	0944-1344, 1614-7499, 1614-7499
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Shrnutí:	α-Cypermethrin (CYP) is a pyrethroid insecticide-like environmental pollutant, widely found in the environment. New research links exposure to high levels of CYP to health damage; however, little is known about the effect of CYP on cardiovascular disease. The purpose of the present study was to evaluate, for the first time, biochemical and cardiovascular changes in male rats resulting from subchronic CYP exposure. The animals were divided into three groups: group 1 served as the control, group 2 (CYP1) received 4 mg/kg of CYP by gavage, and group 3 (CYP2) received 8 mg/kg of CYP by gavage, for 8 weeks each. Results showed that both CYP1 and CYP2 markedly increased plasma concentrations of cardiac markers (LDH, CK-MB, and troponin-T). Moreover, compared to the control group, CYP treatment elevated cardiac oxidative stress, as shown by increased MDA level and decreased activity of SOD, CAT, and GSH-Px. In addition, CYP2 caused a significant increase of 42% the concentration of total cholesterol and more than 75% in triglycerides compared to the control group. Furthermore, DNA fragmentation and collagen deposition were both amplified owing to CYP toxicity. This harmful effect was confirmed by a histological study using H-E and Sirius Red staining. Overall, our results clearly proved the cardiotoxicity caused by α-cypermethrin.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0944-1344 1614-7499 1614-7499
DOI:	10.1007/s11356-019-05336-2