Toxic effect of alpha cypermethrin, an environmental pollutant, on myocardial tissue in male wistar rats

α-Cypermethrin (CYP) is a pyrethroid insecticide-like environmental pollutant, widely found in the environment. New research links exposure to high levels of CYP to health damage; however, little is known about the effect of CYP on cardiovascular disease. The purpose of the present study was to eval...

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Bibliographic Details
Published in:Environmental science and pollution research international Vol. 27; no. 6; pp. 5709 - 5717
Main Authors: Ghazouani, Lakhdar, Feriani, Anouar, Mufti, Afoua, Tir, Meriam, Baaziz, Intissar, Mansour, Hedi Ben, Mnafgui, Kais
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2020
Springer Nature B.V
Subjects:
Animals
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Calcium-binding protein
Cardiotoxicity
Cardiovascular diseases
catalase
Cholesterol
Collagen
Cypermethrin
DNA fragmentation
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental Pollutants - toxicity
Environmental Pollution
Environmental science
enzyme activity
Food Contamination
glutathione peroxidase
Heart
Heart - drug effects
histology
Insecticides
laboratory animals
Male
males
Myocardium - enzymology
Oxidative Stress
Pollutants
pyrethrins
Pyrethrins - toxicity
Pyrethroids
Rats
Rats, Wistar
Risk Assessment and Remediation
Rodents
staining
superoxide dismutase
Toxicity
triacylglycerols
Triglycerides
Troponin
troponin T
Waste Water Technology
Water Management
Water Pollution Control
Oxidative stress
Histology
Cardiotoxicity
Sirius red
Genomic DNA
α-Cypermethrin
ISSN:0944-1344, 1614-7499, 1614-7499
Online Access:Get full text
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Summary:α-Cypermethrin (CYP) is a pyrethroid insecticide-like environmental pollutant, widely found in the environment. New research links exposure to high levels of CYP to health damage; however, little is known about the effect of CYP on cardiovascular disease. The purpose of the present study was to evaluate, for the first time, biochemical and cardiovascular changes in male rats resulting from subchronic CYP exposure. The animals were divided into three groups: group 1 served as the control, group 2 (CYP1) received 4 mg/kg of CYP by gavage, and group 3 (CYP2) received 8 mg/kg of CYP by gavage, for 8 weeks each. Results showed that both CYP1 and CYP2 markedly increased plasma concentrations of cardiac markers (LDH, CK-MB, and troponin-T). Moreover, compared to the control group, CYP treatment elevated cardiac oxidative stress, as shown by increased MDA level and decreased activity of SOD, CAT, and GSH-Px. In addition, CYP2 caused a significant increase of 42% the concentration of total cholesterol and more than 75% in triglycerides compared to the control group. Furthermore, DNA fragmentation and collagen deposition were both amplified owing to CYP toxicity. This harmful effect was confirmed by a histological study using H-E and Sirius Red staining. Overall, our results clearly proved the cardiotoxicity caused by α-cypermethrin.
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ISSN:0944-1344
1614-7499
1614-7499
DOI:10.1007/s11356-019-05336-2